{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:43:39Z","timestamp":1775000619372,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Cheilanthes tenuifolia<\/jats:italic>\n                      (Burm.f.), commonly known as the Sword Fern or Narrow\u2010leaved Cloak Fern, is a little evergreen fern that belongs to the\n                      <jats:italic>Pteridaceae<\/jats:italic>\n                      family and is abundant in various bioactive compounds exerting promising medicinal properties. The current study is designed to evaluate in vivo analgesic and antidiarrheal activity of the methanol leaf extract of\n                      <jats:italic>C. tenuifolia<\/jats:italic>\n                      (MCT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      For this purpose,\n                      <jats:italic>Swiss<\/jats:italic>\n                      albino mice were used to investigate the analgesic and antidiarrheal properties using acetic acid\u2010induced writhing and castor oil\u2010induced diarrhea methods, respectively. The mice were administered orally with different doses of MCT (125, 250, and 500\u2009mg\/kg). The vehicle performed as a negative control (NC), while diclofenac sodium (DCN) (25\u2009mg\/kg), loperamide (LOP) (3\u2009mg\/kg), bismuth subsalicylate (BSS) (10\u2009mg\/kg), and nifedipine (NDP) (2.5\u2009mg\/kg) were supplied as positive controls (PC) (p.o.). In both models, combination treatment of MCT (higher dose) and PC was also administered to different groups of animals for assessing potential antagonistic or synergistic activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Findings of the in vivo study demonstrated that MCT dose\u2010dependently significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) exhibited analgesic and antidiarrheal properties by reduction in the number of writhing and reductions in the total fecal output in contrast to the NC group. Moreover, in combination treatment, MCT significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) synergized the activity of PC in both models, exerting potential analgesic and antidiarrheal activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, MCT has analgesic and antidiarrheal activity; it might be beneficial for the management of pain and diarrhea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70055","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T09:39:04Z","timestamp":1730972344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Qualitative Phytochemical Analysis and Assessments of Analgesic and Antidiarrheal Activity of the Methanolic Leaf Extract of\n                    <i>Cheilanthes tenuifolia<\/i>\n                    : In Vivo Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3180-6372","authenticated-orcid":false,"given":"Asraful Islam","family":"Rakib","sequence":"first","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Dhaka Bangladesh"},{"name":"Phytochemistry and Biodiversity Research Laboratory BioLuster Research Center Ltd. Gopalganj Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0672-6581","authenticated-orcid":false,"given":"Raihan","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Dhaka Bangladesh"},{"name":"Phytochemistry and Biodiversity Research Laboratory BioLuster Research Center Ltd. Gopalganj Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-9720","authenticated-orcid":false,"given":"Md. Shimul","family":"Bhuia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Dhaka Bangladesh"},{"name":"Phytochemistry and Biodiversity Research Laboratory BioLuster Research Center Ltd. Gopalganj Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7560-4041","authenticated-orcid":false,"given":"Md. Sakib Al","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Dhaka Bangladesh"},{"name":"Phytochemistry and Biodiversity Research Laboratory BioLuster Research Center Ltd. Gopalganj Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3705-6967","authenticated-orcid":false,"given":"Salehin","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Dhaka Bangladesh"},{"name":"Phytochemistry and Biodiversity Research Laboratory BioLuster Research Center Ltd. Gopalganj Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddique Akber","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy King Saud University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan Aamer","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Drug Science and Technology University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-3820","authenticated-orcid":false,"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Dhaka Bangladesh"},{"name":"Phytochemistry and Biodiversity Research Laboratory BioLuster Research Center Ltd. Gopalganj Dhaka Bangladesh"},{"name":"Pharmacy Discipline Khulna University Khulna Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v10i5.2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-019-0135-x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed078p175"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4172\/2329-6836.1000308"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061578"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.10.014"},{"key":"e_1_2_11_8_1","volume-title":"StatPearls [Internet]","author":"Milani D. A. 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