{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T13:46:34Z","timestamp":1775051194223,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystemic involvement and unclear etiology. Although SLE could be linked to multiple neuropsychiatric manifestations, the co\u2010occurrence of anorexia nervosa was only described through a few case reports that mainly affected children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>a 40\u2010year\u2010old Filipina woman presented to hospital with a 3\u2010day history of agitation, anorexia and auditory hallucinations. She also had restrictive dietary habits with substantial weight loss and excessive fear of weight gain for the past several months. Her medical history was also noticeable for a 3\u2010month history of erythematous non\u2010itchy skin rash. On examination, the patient was pale and underweight. She had angular stomatitis, bilateral exophthalmos, and diffuse goiter. Skin examination revealed diffuse scaly and erythematous rash over the neck and upper torso with post\u2010inflammatory skin discoloration. Laboratory investigations showed pancytopenia, high serum creatinine, and +1 proteinuria. Further workup confirmed thyrotoxicosis due to Graves disease as well as having multiple positive autoantibodies including antinuclear antibody (ANA) which were suggestive for SLE. A subsequent kidney biopsy demonstrated class IV diffuse lupus nephritis. The patient was treated successfully with intravenous pulse steroid therapy, rituximab, and antithyroid medications with no residual symptoms or laboratory abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The concurrence of anorexia nervosa with SLE and the complete resolution of anorexia nervosa symptoms with immunosuppressive therapy suggest common autoinflammatory pathogenesis for both conditions. Further research is needed to elucidate any potential association between SLE and anorexia nervosa.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70083","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T07:39:42Z","timestamp":1738049982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle\u2010Aged Woman: A Rare Case Report and Literature Review"],"prefix":"10.1002","volume":"13","author":[{"given":"Maen Nizam","family":"Baroudi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Al\u2010Khor Hospital, Hamad Medical Corporation Doha Qatar"},{"name":"Department of Internal Medicine Collage of Medicine Qatar University Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8323-1303","authenticated-orcid":false,"given":"Anwar I.","family":"Joudeh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Al\u2010Khor Hospital, Hamad Medical Corporation Doha Qatar"},{"name":"Department of Internal Medicine Collage of Medicine Qatar University Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Kays","family":"Alattiya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Al\u2010Khor Hospital, Hamad Medical Corporation Doha Qatar"},{"name":"Department of Internal Medicine Collage of Medicine Qatar University Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdo Qaid Ahmed","family":"Lutf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Al\u2010Khor Hospital, Hamad Medical Corporation Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Abuzaid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Al\u2010Khor Hospital, Hamad Medical Corporation Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah","family":"Mahdi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Al\u2010Khor Hospital, Hamad Medical Corporation Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.11.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00138"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1273358"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2021.104326"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3048"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"97","article-title":"Anorexia Nervosa Complicating Systemic Lupus Erythematosus (Sle)","volume":"91","author":"Sloan D.","year":"1998","journal-title":"Irish Medical Journal"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2350\/15-08-1695-CR.1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270367"},{"key":"e_1_2_11_10_1","unstructured":"American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders Fifth Edition Text Revision (DSM\u20105\u2010TR) Washington DC2022."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13953"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10040697"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.106351"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318772021"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)45:5<419::aid-art360>3.0.co;2-x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/GH9.0000000000000448"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.03.014"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16121402"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-015-0202-3"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-020-00227-5"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.8698"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2013.10.003"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510030"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T07:57:38Z","timestamp":1738828658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/iid3.70083"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70083","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70083"}}