{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T21:58:04Z","timestamp":1772488684491,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blocking of Tim\u20103 exerts therapeutic effects in a series of ischemia\u2010reperfusion injury (IRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this work, a cross\u2010clamped aortic arch was conducted to establish SCIRI rat model. Besides, rat spinal microglia was subjected to OGD\/R to mimic I\/R\u2010like conditions in vitro. The in vivo and in vitro therapeutic effects of Tim\u20103 antibody in SCIRI were investigated from these aspects: neuronal apoptosis, neuroinflammation, microglia activation, and polarization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was verified that Tim\u20103 was highly expressed in spinal cord tissues of SCIRI rats and blocking of Tim\u20103 attenuated SCIRI\u2010induced pathological injury, neuronal apoptosis, neuroinflammation, and microglia activation (M1 polarization). In addition, it was verified that Tim\u20103 was highly expressed in OGD\/R\u2010treated rat spinal microglia and blocking of Tim\u20103 attenuated OGD\/R\u2010induced inflammation and spinal microglia activation (M1 polarization).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tim\u20103 antibody can exert therapeutic effects in SCIRI through inhibiting neuroinflammation and promoting microglia polarization from M1 to M2 phenotype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70084","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T10:57:54Z","timestamp":1733482674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Blocking of Tim\u20103 Ameliorates Spinal Cord Ischemia\u2010Reperfusion Injury Through Inhibiting Neuroinflammation and Promoting M1\u2010to\u2010M2 Phenotypic Polarization of Microglia"],"prefix":"10.1002","volume":"12","author":[{"given":"Zhenxing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rehabilitation First Affiliated Hospital of the Guangxi University of Chinese Medicine Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation First Affiliated Hospital of the Guangxi University of Chinese Medicine Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation First Affiliated Hospital of the Guangxi University of Chinese Medicine Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Tuina Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation First Affiliated Hospital of the Guangxi University of Chinese Medicine Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1648-7551","authenticated-orcid":false,"given":"Bolin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency First Affiliated Hospital of the Guangxi University of Chinese Medicine Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs-2023-scp-08"},{"key":"e_1_2_9_3_1","article-title":"Spinal Cord Reperfusion Injury: Case Report, Review of the Literature, and Future Treatment Strategies","volume":"11","author":"Wiginton J. 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