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Patients received SCIT of either Dpt\/Bt (100\/1000 DPP\/mL) or Dpt\/Ld (100\/100 DPP\/mL) in two phases: a rush build\u2010up phase on the first day (0.2\u2009mL and 0.3\u2009mL with a 30\u2010min interval) and a monthly maintenance phase administration (0.5\u2009mL) up to 48 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients were recruited for the study, seven allocated to the Dpt\/Bt group and 33 to the Dpt\/Ld. None experienced immediate or delayed systemic Grade \u2265\u20092 reactions (EAACI classification) (systemic reactions were mostly Grade 1) nor died during the study. Local reactions were mostly mild (0\u201210\u2009cm). Thirty\u2010nine patients (97.5%) experienced at least one adverse event (AE). Of the 283 reported AEs, eight (2.8%) were systemic reactions experienced by six (15%) subjects and 14 (4.9%) were local reactions sustained by ten (25%) subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SCIT treatment of patients with allergic rhinitis or rhinoconjunctivitis and controlled asthma with mixtures of Dpt\/Bt and Dpt\/Ld allergen extracts at maximum concentrations showed a favourable safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70090","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T12:11:51Z","timestamp":1734610311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Trial With a Depigmented, Polymerized Mite Mixture Extract at Maximum Concentrations"],"prefix":"10.1002","volume":"12","author":[{"given":"Carmen","family":"Vidal","sequence":"first","affiliation":[{"name":"Complejo Hospitalario de Santiago Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Romero","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario de Santiago Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lopez\u2010Freire","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario de Santiago Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Carballada\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Hospital Lucus Augusti Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Garcia\u2010Robaina","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Candelaria  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gonzalez\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Hospital Lucus Augusti Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Mendez\u2010Brea","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario de Santiago Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Nieto","sequence":"additional","affiliation":[{"name":"Medical Affairs and Clinical Department LETI Pharma S.L.U. 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