{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:57:39Z","timestamp":1790189859153,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is recognized as a systemic disease for its accompanying comorbidities, among which psychological disorders present a high incidence rate and affect patients\u2019 life quality. Interleukin (IL)\u201017A is the central pathological factor in the pathogenesis and development of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To clarify if psoriasis\u2010induced systemic IL\u201017A increase can mediate the neuronal inflammation and result in depressive\u2010like symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Psoriasiform dermatitis model was established by imiquimod (IMQ) application on male BALB\/c mice and IL\u201017A intervention was performed by lateral ventricular catheterization. Skin structural, histopathological characteristics, and behavioral tests were assessed. Serum IL\u201017A levels were detected by Enzyme\u2010linked immunosorbent assay. mRNA expression of pro\u2010inflammatory factors IL\u20101\u03b2, IL\u20106, and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) as well as anti\u2010inflammatory factors IL\u20104 and IL\u201010 in the hippocampus and cortex were measured by RT\u2010qPCR. The number of microglia and hippocampal neurons was quantified by immunofluorescent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IMQ treatment resulted in significant skin structural and histopathological characters of psoriasiform dermatitis with elevated serum IL\u201017A levels, obvious depressive\u2010like behaviors, microglia activation with increased IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 expression levels in the hippocampus and cortex, and notable inhibition of hippocampal neurogenesis. While, IL\u201017A neutralization by intracerebroventricular injection of anti\u2010IL\u201017A antibody can remarkably inhibit microglia activation and decrease the abnormally increased expression levels of IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 in the hippocampus and cortex of psoriasiform dermatitis mice, promote hippocampal neurogenesis, thus alleviate the depressive\u2010like behaviors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the pathological condition of psoriasis, systemic IL\u201017A elevation can trigger microglia activation, provoke pro\u2010inflammation mediators to release, evoke neuroinflammation, subsequently inhibit hippocampal neurogenesis, and result in depression. IL\u201017A, as an important pathogenic factor in psoriasis, contributes to its critical role in mediating systemic inflammation and depression comorbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70092","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T18:52:38Z","timestamp":1733943158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["IL\u201017A Mediates Depressive\u2010Like Symptoms by Inducing Microglia Activation in Psoriasiform Dermatitis Mice"],"prefix":"10.1002","volume":"12","author":[{"given":"Yue","family":"Dou","sequence":"first","affiliation":[{"name":"Department of Dermatology Binzhou Medical University Hospital Binzhou Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"You","sequence":"additional","affiliation":[{"name":"Department of Dermatology Binzhou Medical University Hospital Binzhou Shandong 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