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In addition, though, extra\u2010pulmonary manifestations of Covid\u201019 have been shown. Furthermore, severe acute respiratory distress syndrome coronavirus type 2 (SARS\u2010CoV\u20102) infection may coexist with several malignancies, including multiple myeloma (MM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This critical literature review aimed to find the potential association between SARS\u2010CoV\u20102 infection and MM in Covid\u201019 patients with underlying MM. Narrative literature and databases search revealed that ARDS is developed in both MM and Covid\u201019 due to hypercalcemia and proteasome dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Notably, the expression of angiogenic factors and glutamine deficiency could link Covid\u201019 severity and MM in the pathogenesis of cardiovascular complications. MM and Covid\u201019 share thrombosis as a typical complication; unlike thrombosis in Covid\u201019, which reflects disease severity, thrombosis does not reflect disease severity in MM. In both conditions, thromboprophylaxis is essential to prevent pulmonary thrombosis and other thromboembolic disorders. Moreover, Covid\u201019 may exacerbate the development of acute kidney injury and neurological complications in MM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlighted that MM patients might be a risk group for Covid\u201019 severity due to underlying immunosuppression and most of those patients need specific management in the Covid\u201019 era.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.701","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T07:18:42Z","timestamp":1668755922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The potential link between Covid\u201019 and multiple myeloma: A new saga"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-2962","authenticated-orcid":false,"given":"Hayder M.","family":"Al\u2010Kuraishy","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Medicine, College of Medicine ALmustansiriyia University Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-8897","authenticated-orcid":false,"given":"Ali I.","family":"Al\u2010Gareeb","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Medicine, College of Medicine ALmustansiriyia University Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali A","family":"Mohammed","sequence":"additional","affiliation":[{"name":"The Chest Clinic, Barts Health NHS Trust Whipps Cross University Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2206-7236","authenticated-orcid":false,"given":"Athanasios","family":"Alexiou","sequence":"additional","affiliation":[{"name":"Department of Science and Engineering Novel Global Community Educational Foundation Hebersham Australia"},{"name":"AFNP Med Wien Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marios","family":"Papadakis","sequence":"additional","affiliation":[{"name":"Department of Surgery II, University Hospital Witten\u2010Herdecke University of Witten\u2010Herdecke Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-425X","authenticated-orcid":false,"given":"Gaber El\u2010Saber","family":"Batiha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine Damanhour University Damanhour Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-021-04232-z"},{"key":"e_1_2_11_3_1","article-title":"Case report: hyperbilirubinemia in gilbert syndrome attenuates Covid\u201019\u2010induced metabolic disturbances","volume":"71","author":"Al\u2010Kuraishy HM","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174196"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2020-138577"},{"key":"e_1_2_11_6_1","first-page":"1034","article-title":"Coronavirus disease (COVID\u201019): comprehensive review of clinical presentation. 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