{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:14:09Z","timestamp":1792030449712,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rosacea is a common inflammatory skin disorder characterized by frequent facial flushing, erythema, telangiectasia, and papules, with a higher incidence observed in individuals aged 30\u221250 years and a tendency to decrease in the elderly. This age\u2010related decline in incidence drew our attention to further explore the relationship between rosacea pathogenesis and aging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed the incidence of rosacea across 8340 individuals without systemic diseases. The effects of LL37\u2010induced rosacea\u2010like erythema and inflammation were evaluated in both young and aged mice. Immunofluorescence analysis was performed to assess microvessel density, whereas the expression levels of angiogenesis\u2010related factors, including matrix metalloproteinases (MMPs) and vascular endothelial growth factor \u03b1 (VEGF\u03b1), were quantified. Additionally, immune responses were assessed at both the cellular and systemic levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Aged mice displayed milder LL37\u2010induced rosacea\u2010like erythema and inflammation compared to their young counterparts. Immunofluorescence analysis revealed a decrease in microvessel density in rosacea models of the aged group. The expression of angiogenesis\u2010related factors, including MMPs and VEGF\u03b1, was decreased in aged mice compared to young mice, indicating a reduced responsiveness to LL37 stimulation. Furthermore, we found that suppressed Th1\u2010 and Th17\u2010polarized immune responses, one of the major pathogenic mechanisms of rosacea, were reduced in aged mice in response to LL37 stimulation at both cellular and systemic levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings suggest that impaired angiogenesis and attenuated Th1\/Th17 immune responses underlie the age\u2010related decline in rosacea incidence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70108","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T14:04:45Z","timestamp":1734530685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impaired Angiogenesis and Th1\/Th17 Polarization: A Possible Explanation for the Decreased Incidence of Rosacea in the Aged"],"prefix":"10.1002","volume":"12","author":[{"given":"Juan","family":"Long","sequence":"first","affiliation":[{"name":"Department of Dermatology The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital) Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-775X","authenticated-orcid":false,"given":"Tangxiele","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Affiliated Children's 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