{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:55:38Z","timestamp":1791640538568,"version":"4.3.4"},"reference-count":86,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The objective of this systematic review was to identify genetic variants of the\n                      <jats:italic>IL\u201023<\/jats:italic>\n                      ,\n                      <jats:italic>IL\u201017<\/jats:italic>\n                      ,\n                      <jats:italic>IL\u201023R<\/jats:italic>\n                      and\n                      <jats:italic>IL\u201017R<\/jats:italic>\n                      genes and isoforms and its possible association with increased development of periodontitis and peri\u2010implantitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was prepared according to the guidelines, registered in the OSF database with the registration number: 10.17605\/OSF. IO\/X95ZC. The electronic search was performed in four databases: PubMed, Scopus, Web of Science, and Google Scholar from 1984 until March 15th, 2024. The JBI Critical Appraisal Checklist for Case\u2010Control Studies was used to assess the quality of included studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen papers with a case\u2010control design were those that ultimately met the eligibility criteria. A total of 3904 individuals (2315 with periodontitis and 90 with peri\u2010implantitis), and 1589 healthy subjects) were studied. The age range of the study population was 14\u201370 years, with a mean age\u2009\u00b1\u2009(SD) of 40.43\u2009\u00b1\u20096.33 years. A total of 28 genetic variants corresponding to the\n                      <jats:italic>IL\u201017A<\/jats:italic>\n                      (rs 2275913, rs 3819024, rs 10484879)\n                      <jats:italic>IL\u201017F<\/jats:italic>\n                      (rs 763780),\n                      <jats:italic>IL\u201017R<\/jats:italic>\n                      (rs 879576) and\n                      <jats:italic>IL\u201023R<\/jats:italic>\n                      (rs 11209026) genes were analyzed in this study. Six (33.3%) studies found an association between the\n                      <jats:italic>IL\u201017A<\/jats:italic>\n                      197\u2009G\/A (rs 2275913) genetic variant and peri\u2010implantitis and periodontitis. One study (5.5%) found an association between the\n                      <jats:italic>IL\u201017A<\/jats:italic>\n                      rs10484879 variant and peri\u2010implantitis and periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Six polymorphisms were evaluated, highlighting rs 2275913 of the cytokine IL\u201017A in patients with periodontitis or peri\u2010implantitis. Only 50% of studies found an association despite having a small sample. This suggests that other factors such as the degree of disease, systemic diseases and ethnic groups studied may play a role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70147","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T08:35:51Z","timestamp":1738312551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Genetic Variants of the\n                    <i>IL\u201023<\/i>\n                    \/\n                    <i>IL\u201017<\/i>\n                    Axis and Its Association With Periodontal Disease: A Systematic Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-0334","authenticated-orcid":false,"given":"Ruth","family":"Rodr\u00edguez\u2010Monta\u00f1o","sequence":"first","affiliation":[{"name":"Department of Health and Illness as an Individual and Collective Process University Center of Tlajomulco, 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