{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:05:55Z","timestamp":1789175155082,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Testing of antiphospholipid antibodies (aPLs) has attracted increasing attention for its association with thrombosis and pregnancy loss. However, few studies reported long\u2010term monitoring outcomes of patients who experienced pregnancy loss and exhibited positivity for aPLs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated the causes of fetal death in five cases with positive aPLs and traced the patients for changes in aPLs, subsequent pregnancy outcomes, and thrombotic events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a report of five typical cases from a prospective cohort study on the diagnosis of antiphospholipid syndrome (APS) in patients who were hospitalized for fetal death in Xining, China. Long\u2010term follow\u2010up was conducted and repeat aPL testing was recommended when the patients were confirmed or suspect APS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All five patients had subsequent pregnancies that resulted in term livebirths. None of the patients experienced thrombotic events. One showed progression of aPL serostatus from alone IgM of a\u03b22GP\u20101 to both IgM and IgG of a\u03b22GP\u20101, two exhibited fluctuation of aPL serostatus, and one had negative conversion, and the other one had not retested aPLs and did not receive any intervention with uneventful subsequent pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The aPLs of a patient with APS may develop or may disappear, so long\u2010term monitoring cannot be discounted. Also, a woman who has experienced fetal death and exhibits positivity for aPLs may not necessarily be a patient with APS, as there are a variety of conditions in which aPLs appear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70158","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T06:03:46Z","timestamp":1739426626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Follow\u2010Up of Patients With Positive Antiphospholipid Antibodies After Fetal Death: Five Typical Cases From a Prospective Cohort Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-8597","authenticated-orcid":false,"given":"Anxia","family":"Xie","sequence":"first","affiliation":[{"name":"Research Center for High Altitude Medicine Qinghai University Xining China"},{"name":"Department of Obstetrics Qinghai Provincial People's Hospital Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Qinghai Red Cross Hospital Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Qinghai Red Cross Hospital Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Qinghai Provincial People's Hospital Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Qinghai Red Cross Hospital Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Qinghai Red Cross Hospital Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-9769","authenticated-orcid":false,"given":"Xiaoxing","family":"Wei","sequence":"additional","affiliation":[{"name":"Research Center for High Altitude Medicine Qinghai University Xining China"},{"name":"Medical College Qinghai University Xining 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