{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:55:19Z","timestamp":1753869319986,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Renal transplant recipients are at higher risk of COVID\u201019 infection due to chronic comorbidities and immunocompromised state. Limited information is available in Nepal regarding this infection among organ transplantation patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cross\u2010sectional study was conducted on 601 patients to assess the impact of COVID\u201019 among patients who underwent renal transplant surgery at Shahid Dharmabhakta National Transplant Center (SDNTC), Bhaktapur. All the renal transplant patients who were COVID\u201019 confirmed through PCR tests were included. A self\u2010developed, semi\u2010structured telephone interview schedule was utilized for data collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the patients who responded to our telephone calls, more than a quarter (37.9%) were diagnosed as COVID\u201019 positive. The mortality rate was relatively low at 5.7% overall, but significantly higher at 14.9% among those with COVID\u201019 positive. Hypertension and diabetes mellitus were the top two comorbid conditions. The common reporting symptom was fever followed by cough. Interestingly, 23.7% of COVID\u201019\u2010positive patients were hospitalized, and among them, 72.2% were admitted for more than 2 days. Notably, 65.8% of the COVID\u201019 patients were not vaccinated and among vaccinated ones, only 17.1% of patients were fully vaccinated. The most common vaccine was Vero Cell. There was sixfold increased chance of COVID\u201019 infection among unvaccinated patients than vaccinated ones. However, there was no significant association between mortality and age, sex, occupation and vaccination status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the heightened vulnerability of renal transplant recipients to COVID\u201019 as significant portion of the studied patients tested positive for COVID\u201019, with a notable mortality rate among these patients. The findings underscore the critical role of vaccination, as a considerable number of the COVID\u201019 positive patients were unvaccinated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70187","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T13:33:36Z","timestamp":1744983216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of COVID\u201019 on Renal Transplant Recipients in a National Transplant Center"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8082-4485","authenticated-orcid":false,"given":"Pooja","family":"Koirala","sequence":"first","affiliation":[{"name":"Department of Nursing Shahid Dharmabhakta National Transplant Centre Bhaktapur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pukar Chandra","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Surgery and 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