{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:11:50Z","timestamp":1791353510201,"version":"4.3.1"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malaria is a life\u2010threatening disease caused by Plasmodium parasites, transmitted through the bites of infected female Anopheles mosquitoes. It remains a major global health issue, with 263 million cases and 597,000 deaths in 2023, primarily affecting young children and pregnant women. This review evaluates awareness, acceptance, hesitancy, and willingness to pay (WTP) for the RTS,S\/AS01 malaria vaccine, along with the key factors influencing these outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was conducted in Web of Science, PubMed, and Embase, covering publications up to 18 June 2024. Observational studies assessing awareness, acceptance, hesitancy, and WTP for the malaria vaccine in endemic regions were included. Two independent reviewers screened the studies. Data extraction was performed using Nested Knowledge software and analyzed with R v.4.4. Pooled prevalences were estimated using random\u2010effects models, and heterogeneity was assessed with the I\u00b2 statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen studies with 21,975 participants provided insights into malaria vaccine dynamics: 32% awareness (95% CI, 18%\u201350%), 83% acceptance (95% CI, 75%\u201389%), 14% hesitancy (95% CI, 7%\u201326%), and 58% WTP (95% CI, 34%\u201379%). Key determinants of acceptance included age, where younger adults (18\u201324 years) showed lower acceptance (OR\u2009=\u20090.64, 95% CI, 0.35\u20130.93). Employment, particularly farmers, had higher acceptance rates (OR\u2009=\u20093.20, 95% CI, 1.00\u20137.40). Lower socioeconomic status and larger family sizes were associated with decreased acceptance (OR\u2009=\u20090.18, 95% CI, 0.02\u20130.38).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This review revealed an 83% acceptance rate for the malaria vaccine, with variability in awareness (32%), hesitancy (14%), and willingness to pay (58%). Age, employment, and socioeconomic status were significant determinants of acceptance. However, due to potential publication bias and high heterogeneity, these findings should be cautiously interpreted. The results highlight the necessity for targeted interventions to enhance vaccine acceptance. Further research is required to elucidate factors that influence vaccine acceptance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70205","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:46:02Z","timestamp":1747223162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta\u2010Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay"],"prefix":"10.1002","volume":"13","author":[{"given":"Ganesh","family":"Bushi","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Lovely Professional University Phagwara Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahalaqua Nazli","family":"Khatib","sequence":"additional","affiliation":[{"name":"Division of Evidence Synthessis, Global Consortium of Public Health and Research Datta Meghe Institute of Higher Education Wardha Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka Jyothi.","family":"S","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Genetics School of Sciences, JAIN (Deemed to be University) Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwanjot","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Allied Healthcare and Sciences Vivekananda Global University Jaipur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine NIMS University Jaipur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhaib","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Chandigarh Pharmacy College, Chandigarh Group of College, Jhanjeri Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ravi","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Raghu Engineering College Visakhapatnam Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Singh","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Division of Research and Innovation Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teena","family":"Vishwakarma","sequence":"additional","affiliation":[{"name":"IES Institute of Pharmacy IES University Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Malik","sequence":"additional","affiliation":[{"name":"New Delhi Institute of Management Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quazi Syed","family":"Zahiruddin","sequence":"additional","affiliation":[{"name":"South Asia Infant Feeding Research Network, Division of Evidence Synthesis, Global Consortium of Public Health and Research Datta Meghe Institute of Higher Education Wardha Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Shabil","sequence":"additional","affiliation":[{"name":"University Center for Research and Development, Chandigarh University Mohali Punjab India"},{"name":"Medical Laboratories Techniques Department AL\u2010Mustaqbal University Hillah Babil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4771-4089","authenticated-orcid":false,"given":"Rachana","family":"Mehta","sequence":"additional","affiliation":[{"name":"Clinical Microbiology, RDC Manav Rachna International Institute of Research and Studies Faridabad Haryana India"},{"name":"Dr Lal PathLabs \u2010 Nepal Maharajgunj Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5017-083X","authenticated-orcid":false,"given":"Sanjit","family":"Sah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre Dr. D. Y. Patil Vidyapeeth (Deemed\u2010to\u2010be\u2010University), Pimpri Pune India"},{"name":"Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital Dr. D. Y. 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