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The disease is influenced by a combination of genetic factors, environmental triggers, immune system dysfunction, and its systemic nature with comorbidities like cardiovascular diseases and depression. Macrophages, essential immune cells, play a critical role in the pathogenesis of psoriasis, displaying various functions and activation states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to investigate the impact of M2 macrophages on the progression and management of psoriasis, particularly their ability to support tissue healing and reduce inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>M1 macrophages are involved in early inflammation and pro\u2010inflammatory responses when activated by LPS and IFN\u2010\u03b3, while M2 macrophages are activated by IL\u20104 and IL\u201013 to promote anti\u2010inflammatory and tissue repair processes. Imbalance in M1 and M2 polarization can worsen autoimmune conditions such as psoriasis, underscoring the need to regulate macrophage phenotypes for effective disease management. Recent research suggests that targeting M2 macrophages could be a promising therapeutic approach for treating psoriasis, especially through advanced biologic treatments such as anti\u2010IL\u201017 and anti\u2010IL\u201023 therapies. Enhancing the function of M2 macrophages has been shown to reduce inflammation and improve outcomes in psoriatic conditions, potentially lowering the risk of comorbidities through early intervention and personalized treatment. Biomarkers like CD163(+) M2 macrophages are associated with disease progression, while treatments that enhance M2 macrophage function, such as PSORI\u2010CM02 and Treg\u2010of\u2010B cell therapies, show potential in alleviating psoriasis symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Understanding the crucial role of M2 macrophages in psoriasis could pave the way for innovative treatment approaches that regulate immune responses and enhance patient care. Further exploration of macrophage biology in psoriasis may provide fresh perspectives on personalized therapeutic options for managing psoriasis and other inflammatory skin conditions, ultimately improving patient care and quality of life for individuals with this chronic skin condition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70211","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T08:19:41Z","timestamp":1750407581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The M2 Macrophages Importance Role in Psoriasis"],"prefix":"10.1002","volume":"13","author":[{"given":"Ahmed Hussein Hasan","family":"Alshihmani","sequence":"first","affiliation":[{"name":"Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Immunology Department, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Immunology Department, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramiar Kamal","family":"Kheder","sequence":"additional","affiliation":[{"name":"Medical Laboratory Science Department, College of Science University of Raparin Rania Sulaymaniyah Iraq"},{"name":"Department of Medical Analysis, Faculty of Applied Science Tishk International University Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsane","family":"Fadaee","sequence":"additional","affiliation":[{"name":"Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Immunology Department, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-4170","authenticated-orcid":false,"given":"Seyed\u2010Alireza","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Immunology Department, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9111511"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.09.023"},{"issue":"2","key":"e_1_2_16_4_1","article-title":"An Investigation of the Relationship Between HLA\u2010CW06 and Psoriasis in Iranian Patients Using Sequence\u2010Specific Primers","volume":"9","author":"Fini Z. 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