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Cav\u20101 is involved in a wide range of cellular functions and plays a key role in regulating signaling pathways related to immune responses and inflammation. Recently, research on Cav\u20101 in autoimmune diseases (AIDs) has garnered significant interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This paper provides an overview of the research on Cav\u20101's involvement in AIDs, including rheumatoid arthritis, systemic lupus erythematosus, Sj\u00f6gren syndrome, anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitis, systemic sclerosis, connective tissue disease\u2010associated interstitial lung disease, autoimmune disorders of the nervous system, autoimmune uveitis, autoimmune thyroid disease, and autoimmune myocarditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cav\u20101 plays a critical role in various AIDs, acting as a key protein in inflammatory and immune cells. It regulates multiple signaling processes by controlling the translocation of signaling molecules and modulating various pathways. Cav\u20101 is increasingly recognized as a biomarker in certain AIDs and may become pivotal in treating these diseases in the future.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cav\u20101 is a crucial player in the pathogenesis of many AIDs and has the potential to serve as both a diagnostic marker and a therapeutic target for these diseases. As research into Cav\u20101 deepens, it may offer new insights into the diagnosis, treatment, and drug sensitivity of AIDs, emerging as a promising target for future therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70230","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T09:46:29Z","timestamp":1754646389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Revolutionizing Autoimmune Research: The Role of Caveolin\u20101"],"prefix":"10.1002","volume":"13","author":[{"given":"Yanan","family":"Gao","sequence":"first","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Mi","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingren","family":"Deng","sequence":"additional","affiliation":[{"name":"Jiexiu People's Hospital Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Jia","sequence":"additional","affiliation":[{"name":"Jiexiu People's Hospital Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Hu","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Ji","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyao","family":"He","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8031-5525","authenticated-orcid":false,"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1424","article-title":"Fine Structure of Blood Capillaries","volume":"24","author":"Palade G. 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