{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:42:57Z","timestamp":1784824977462,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to investigate whether carbon monoxide (CO) can alleviate cardiomyocyte pyroptosis by downregulating the IL\u201033\/ST2L axis in diabetic cardiomyopathy (DCM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The diabetic mouse model was established and treated with CO\u2010releasing molecule\u20102 (CORM\u20102) or invalid CORM\u20102 (iCORM\u20102). For in vitro studies, cardiomyocytes were treated with high glucose (HG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HG\u2010treated cardiomyocytes exhibited increased IL\u201033, ST2L, and pyroptosis\u2010related protein expression compared with that in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Treatment with recombinant IL\u201033 further increased the expression of HG\u2010induced pyroptosis\u2010related proteins (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Compared with control mice, DCM mice showed reduced cardiac function and elevated expression of IL\u201033, ST2L, and pyroptosis\u2010related proteins (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Intervention with CORM\u20102 ameliorated cardiac injury, and decreased the expression of IL\u201033, ST2L, and pyroptosis\u2010related proteins in vivo and in vitro (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, iCORM\u20102 had no effect both in vivo and in vitro.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, CO may inhibit cardiomyocyte pyroptosis by downregulating the IL\u201033\/ST2L axis in DCM mice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70231","type":"journal-article","created":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T03:39:54Z","timestamp":1756006794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Carbon Monoxide Alleviates Cardiomyocyte Pyroptosis in Diabetic Cardiomyopathy by Downregulating the IL\u201033\/ST2L Axis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7980-5861","authenticated-orcid":false,"given":"Chunjie","family":"Jiang","sequence":"first","affiliation":[{"name":"Jinan University Affiliated Guangzhou Red Cross Hospital Guangzhou China"},{"name":"Department of Nutrition and Food Hygiene, 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