{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:35Z","timestamp":1792788515559,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Corticosteroid\u2010resistant secondary immune thrombocytopenia (ITP) is a challenging condition in clinical practice. This study aimed to explore the clinical and immunological characteristics of corticosteroid\u2010resistant secondary ITP associated with connective tissue diseases (CTD\u2010ITP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of 201 CTD\u2010ITP hospitalized patients between 2014 and 2022. Patients were categorized as corticosteroid\u2010resistant or corticosteroid\u2010sensitive, and their demographic, clinical, and immunological data were compared. Logistic regression analysis was employed to identify independent predictors of corticosteroid resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Corticosteroid resistance was observed in 27.4% of patients. Compared with the corticosteroid\u2010sensitive group, the corticosteroid\u2010resistant group exhibited a higher percentage of CD3<jats:sup>+<\/jats:sup> T cell (71.38% vs. 64.70%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) and CD3<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup> T cell (38.55% vs. 28.95%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), but a lower percentage of CD19<jats:sup>+<\/jats:sup> B cell (13.70% vs. 22.45%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) in peripheral blood. No significant differences were found in other demographics, clinical features, or autoantibody profiles. The multivariable logistic regression analysis showed that higher percentage of CD3<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup> T cells (OR\u2009=\u20091.170, 95% CI: 1.014\u20131.350, <jats:italic>p<\/jats:italic>\u2009=\u20090.031) was an independent risk factor for corticosteroid resistance in CTD\u2010ITP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study revealed the potential role of higher CD3<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup> T cells in corticosteroid resistance among CTD\u2010ITP patients, and provided the potential biomarker for predicting corticosteroid therapy response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70236","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T11:04:15Z","timestamp":1753787055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics of Corticosteroid\u2010Resistant 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