{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:12:12Z","timestamp":1788387132292,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The current systematic review and meta\u2010analysis aims to assess the safety and immunogenicity of the anticaries vaccines currently available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Electronic searches of PubMed, Scopus, Web of Science and Science Direct were performed. Studies assessing the safety and effectiveness of the anticaries vaccination, including the dose, plasmids, serum IgG and IgA levels after immunization, were included. Studies in which animals were used for anticaries vaccine were also included. Combining more than one trial was done to estimate the pooled intervention effect using the meta\u2010analysis when studies examined the same intervention and outcomes with comparable methods in similar populations. The continuous data was pooled using the inverse variance method, and dichotomous data using the Mantel\u2010Haenszel method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 4701 records, only 17 publications met the eligibility criteria. Although all studies were assessed as having an overall low risk of bias, certain domains (D3, D5, and D7) exhibited a high risk across most studies. The pooled RR, derived using a random\u2010effects model, was 0.53 (95% CI: 0.46\u20130.62), indicating a statistically significant 47% reduction in risk across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is excellent potential for dental caries vaccines to transform oral health in the future. Various vaccines, such as Killed Formalin\u2010treated Donor strain 2 \u2010 recombinant Protein Antigen c and anti\u2010CAT\u2010SYIIgY antibodies, have demonstrated prophylactic effects against Streptococcus mutans colonization on teeth. These interventions exhibit a sustained reduction in S. mutans colonization, which may contribute to the prevention of dental caries. A vaccination of this kind would significantly lower tooth decay prevalence and the financial and health costs that go along with it.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70253","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T15:13:01Z","timestamp":1757085181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing the Efficacy and Immunogenicity of Anticaries Vaccine\u2014A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"13","author":[{"given":"Gunjan","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Public Health Dentistry, Kalinga Institute of Dental Sciences (KIDS) Kalinga Institute of Industrial Technology (KIIT) Deemed to Be University Bhubaneswar 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