{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:13Z","timestamp":1786977913986,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The available evidence increasingly indicates that SERPINB3\/4 plays a pivotal role in the progression of inflammatory diseases and may serve as a valuable biomarker for atopic dermatitis and psoriasis. However, the expression of SERPINB3\/4 in the serum of patients with moderate\u2010to\u2010severe prurigo nodularis (PN) remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To find a promising biomarker for monitoring the severity and activity of moderate\u2010to\u2010severe PN patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 41 patients with moderate\u2010to\u2010severe PN and 20 healthy subjects were included in the study. Enzyme\u00adlinked immunosorbent assay (ELISA) was performed to determine serum SERPINB3\/4 expression. Cutaneous SERPINB3\/4 expression was evaluated by immunohistochemistry (IHC). Serum SERPINB3\/4 levels were correlated with PN disease severity and activity scores, hematological parameters, and systemic inflammatory markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SERPINB3\/4 expression was found to be significantly increased in the serum and lesions of PN in comparison to healthy subjects. In patients with PN, the expression of serum SERPINB3\/4 was significantly elevated in subjects with higher investigator global assessment (IGA) scores, while exhibiting a notable decline in patients with higher pruritus numeric rating scale (P\u2010NRS) scores. Positive correlations were observed between serum SERPINB3\/4 levels and peripheral eosinophil count, eosinophil ratio, and eosinophil\u2010to\u2010lymphocyte ratio (ELR) in patients with PN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SERPINB3\/4 expression was increased in PN sera and lesions. Serum SERPINB3\/4 expression was positively correlated with PN severity and peripheral eosinophil\u2010related parameters, suggesting its potential as a promising biomarker for PN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70263","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:18:12Z","timestamp":1758799092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum SERPINB3\/4 in Moderate\u2010to\u2010Severe Prurigo Nodularis: A Potential Biomarker for Disease Severity and Eosinophil\u2010Related Parameters"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0558-091X","authenticated-orcid":false,"given":"Jiali","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking University Shenzhen Hospital, Institute of Dermatology, Shenzhen Peking University\u2014The Hong Kong University of 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