{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:36:21Z","timestamp":1777523781382,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010term outcome data from real\u2010world studies of the bictegravir emtricitabine tenofovir alafenamide fumarate (B\/F\/TAF) regimen in the treatment of elderly patients with HIV\/AIDS are still limited. This study evaluated the real\u2010world effectiveness and safety of B\/F\/TAF in elderly HIV\u2010infected individuals in southwest China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was an observational, single\u2010center, retrospective study that enrolled antiretroviral therapy (ART)\u2010na\u00efve (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009149) and ART\u2010experienced (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009143) patients with HIV infection between January 2021 and April 2024. The main endpoint was the viral suppression rate of HIV RNA\u2009&lt;\u200950 copies\/ml at 48 weeks, and change in CD4 cell count, CD4\/CD8 ratio, body weight, blood lipid and safety were secondary endpoints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proportions of ART\u2010na\u00efve and ART\u2010experienced HIV\u2010infected cases with VL\u2009&lt;\u200950 copies\/mL at 48 weeks were 93.1% and 92.9%, respectively. CD4 cell counts and CD4\/CD8 ratios increased significantly from baseline at 48 weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the treatment\u2010naive group, ALT, AST, eGFR, and Glu decreased significantly from baseline at 48 weeks, while body weight, Scr, TC, HDL, and LDL increased significantly. Among patients previously administered ART, eGFR increased significantly from baseline at 48 weeks, while AST, LDL, and Scr decreased significantly; other indicators showed no significant changes from baseline. The incidence rates of adverse events were 11.7% and 4.3% in treatment\u2010na\u00efve and treatment\u2010experienced, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For elderly HIV\/AIDS patients, B\/F\/TAF is a safe option to achieve and maintain virological suppression and immune recovery. In terms of lipid metabolism, the metabolic effects of BIC\/FTC\/TAF in the treated patients are not significant, and the effects in untreated patients require longer follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70264","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T03:43:40Z","timestamp":1764128620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Efficacy and Safety of BIC\/TAF\/FTC in Elderly HIV\u2010Infected Individuals in Southwest China: A Retrospective Observation Study"],"prefix":"10.1002","volume":"13","author":[{"given":"Shujing","family":"Ma","sequence":"first","affiliation":[{"name":"Infection Department Guiyang Public Health Clinical Center Guiyang Guizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxin","family":"Xie","sequence":"additional","affiliation":[{"name":"Infection Department Guiyang Public Health Clinical Center Guiyang Guizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Fu","sequence":"additional","affiliation":[{"name":"Infection Department Guiyang Public Health Clinical Center Guiyang Guizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Gan","sequence":"additional","affiliation":[{"name":"Infection Department Guiyang Public Health Clinical Center Guiyang Guizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Infection Department Guiyang Public Health Clinical Center Guiyang Guizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Infection Department Guiyang Public Health Clinical Center Guiyang Guizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-5623","authenticated-orcid":false,"given":"Hai","family":"Long","sequence":"additional","affiliation":[{"name":"Infection Department Guiyang Public Health Clinical Center Guiyang Guizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.10.002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.09.031"},{"key":"e_1_2_12_4_1","unstructured":"National AIDS and Sexually Transmitted Diseases Epidemic in the Third Quarter of 2018.Chinese AIDS and Sexually Transmitted Diseases 2411(2018):1075."},{"issue":"1","key":"e_1_2_12_5_1","first-page":"96","article-title":"[Hiv Infection Rate in People Aged 50 Years and Older in China: A Meta\u2010Analysis","volume":"41","author":"Zhang H. X.","year":"2020","journal-title":"Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.10.004"},{"issue":"03","key":"e_1_2_12_7_1","first-page":"297","article-title":"Analysis of Injury Death Trend of the Elderly in Huzhou From 2010 to 2020","volume":"34","author":"Yu M.","year":"2022","journal-title":"Preventive Medicine"},{"key":"e_1_2_12_8_1","unstructured":"P.Kasaie C.Stewart E.Humes et al. Multimorbidity in People With HIV Using ART in the US: Projections to 2030.Presented at: Conference on Retroviruses and Opportunistic Infections (CROI); March 6\u201310 2021; Virtual. Oral 102 https:\/\/www.croiconference.org\/abstract\/multimorbidity-in-people-with-hiv-using-art-in-the-us-projections-to-2030\/."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13319"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S331647"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.965836"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166661"},{"issue":"8","key":"e_1_2_12_13_1","first-page":"779","article-title":"China AIDS Diagnosis and Treatment Guidelines (2024 edition)","volume":"30","author":"Shen Y. Z.","year":"2024","journal-title":"China AIDS and STD"},{"key":"e_1_2_12_14_1","first-page":"1","article-title":"2016 Chinese Guidelines for the Management of Dyslipidemia in Adults","volume":"15","author":"Jun\u2010Ren Z. H. U.","year":"2018","journal-title":"Journal of Geriatric Cardiology : JGC"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32299-7"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac018"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13467"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2305692"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2023.2292544"},{"issue":"06","key":"e_1_2_12_20_1","first-page":"481","article-title":"Expert Consensus on Clinical Diagnosis and Treatment of Aids Immune Reconstruction Insufficiency (2023 Edition)","volume":"36","author":"Taisheng L.","year":"2023","journal-title":"Infectious Disease Information"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.18683\/germs.2021.1286"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0181-1"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101991"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10081823"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(22)00094-7"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00056-0"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T11:36:44Z","timestamp":1764243404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/iid3.70264"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70264","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2024-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70264"}}