{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:57:50Z","timestamp":1783727870851,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lower respiratory tract infections (LRTIs) impose a significant global burden, with over 400 million cases annually. This study compares the clinical features of adults hospitalized with respiratory syncytial virus (RSV) and COVID\u201019, two viral pathogens with similar presentations but differing epidemiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study analyzed 100 adult cases with PCR\u2010confirmed RSV or COVID\u201019, admitted to the hospital from January 2022 to March 2023. Data on clinical, sociodemographic, radiological, treatment, and laboratory variables were extracted from records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both cohorts consisted of elderly patients (&gt;\u200970 years) with multiple comorbidities. Notably, the RSV group had a higher prevalence of CHF (24% vs. 10%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and COPD (29% vs. 9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Radiologically, 51% of RSV patients had normal findings, whereas 48% of COVID\u201019 patients exhibited bilateral pneumonia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Antimicrobial treatment was administered to 75% of RSV patients compared to 41% of COVID\u201019 patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). RSV patients had marginally higher leukocyte and neutrophil counts, while COVID\u201019 patients showed significantly elevated CRP, ferritin, LDH, ALT, and potassium levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Distinct profiles were identified between hospitalized RSV and COVID\u201019 patients. RSV patients, mostly older with CHF and COPD, were more likely to receive antibiotics, possibly reflecting the lack of targeted therapies. In contrast, COVID\u201019 patients exhibited higher inflammation and lung involvement. These findings highlight the need to refine treatment protocols, enhance antimicrobial stewardship, and develop specific RSV therapies alongside preventive strategies for high\u2010risk groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70281","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T03:33:21Z","timestamp":1764128001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Respiratory Syncytial Virus and COVID\u201019 in Hospitalized Adults in Spain: Clinical, Radiological Features and Antimicrobial Use"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-5078","authenticated-orcid":false,"given":"Jose\u2010Reynaldo","family":"Homen Fernandez","sequence":"first","affiliation":[{"name":"Servicio de Enfermedades Infecciosas, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) Hospital Cl\u00ednico San Carlos Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Armenteros","sequence":"additional","affiliation":[{"name":"Centro Sanitario Sandoval Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-1276","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Valls Carb\u00f3","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) Hospital Cl\u00ednico San Carlos Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Barrado","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9037-4377","authenticated-orcid":false,"given":"Carolina","family":"Olmos\u2010Mata","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) Hospital 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de Sanidad \u201cCuadro de mando resumen de datos de vacunaci\u00f3n [Summary Dashboard of Vaccination Data] \u201d accessed July 1 2024 https:\/\/www.sanidad.gob.es\/areas\/alertasEmergenciasSanitarias\/alertasActuales\/nCov\/pbiVacunacion.htm."},{"key":"e_1_2_9_25_1","unstructured":"Grupo de Trabajo vacunaci\u00f3n frente VRS en poblaci\u00f3n adulta de la Ponencia de Programa y Registro de Vacunaciones \u201cEvaluaci\u00f3n de La Vacunaci\u00f3n Frente a VRS En La Poblaci\u00f3n Adulta [Evaluation of RSV Vaccination in the Adult Population. 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