{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T17:37:40Z","timestamp":1769794660550,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anti\u2010signal recognition particle (anti\u2010SRP) antibodies are myositis\u2010specific autoantibodies associated with immune\u2010mediated necrotizing myopathy. This study was undertaken to better understand how patients with anti\u2010SRP antibodies have been managed at our tertiary centre and to assess the spectrum of clinical features and outcomes in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective evaluation of 25 patients with anti\u2010SRP antibodies identified via line\u2010blot immunoassay at a tertiary care centre (2019\u20132024). Demographic, clinical, serological, and imaging data were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The group of patients had a mean age of 60.1 years, with a female\u2010to\u2010male ratio of 10:15. Eight patients (32%) were diagnosed with myositis, primarily presenting with proximal muscle weakness. Interstitial lung disease was observed in 53% of the group of patients, and 50% of the subset of patients with myositis. Coexisting myositis\u2010specific autoantibodies were present in 32%, and 48% had positive antinuclear antibody titres (\u2265\u20091:400). Cardiac involvement was reported in two myositis patients. Corticosteroids, often combined with mycophenolate mofetil or other immunosuppressants, formed the basis of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti\u2010SRP antibodies are associated with a heterogeneous clinical spectrum, with many patients lacking myositis features. There was a high prevalence of coexisting autoantibodies. Further studies are needed to elucidate the pathogenic role of anti\u2010SRP and optimise management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70297","type":"journal-article","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T18:04:52Z","timestamp":1768154692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics of Patients With Anti\u2010Signal Recognition Particle Antibody: A Cohort Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Ameen","family":"Jubber","sequence":"first","affiliation":[{"name":"University Hospitals of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maumer","family":"Durrani","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Almayahi","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4824-1340","authenticated-orcid":false,"given":"Kehinde","family":"Sunmboye","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester Leicester UK"},{"name":"University of Leicester Leicester 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Case of Interstitial Pneumonia With Anti\u2010Signal Recognition Particle (SRP) Antibody Without Myopathy","volume":"48","author":"Kono M.","year":"2010","journal-title":"Nihon Kokyuki Gakkai Zasshi = Journal of the Japanese Respiratory Society"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2016.10.009"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.7962"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.0303-17"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11484"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-01900-2"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-023-01363-5"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.04.001"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000002043"}],"container-title":["Immunity, 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