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Increasing evidence suggests that CAR\u2010T cells can precisely target pathogenic immune populations, offering durable remission and immune homeostasis restoration in neuroimmunological disorders such as myasthenia gravis (MG), neuromyelitis optica spectrum disorder (NMOSD), and multiple sclerosis (MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant publications and clinical trial data up to September 2025 were systematically reviewed to summarize the mechanisms, therapeutic targets, safety profiles, and translational applications of CAR\u2010T therapy in autoimmune diseases of the nervous system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Preclinical and early clinical studies demonstrate that CD19\u2010 and BCMA\u2010directed CAR\u2010T therapies effectively deplete autoreactive B cells with significant symptom improvement and minimal cytokine release syndrome or neurotoxicity. Novel constructs such as chimeric autoantibody receptor (CAAR)\u2010T and CAR\u2010regulatory T (CAR\u2010Treg) cells enhance specificity and immune tolerance. Innovations including allogeneic \u201coff\u2010the\u2010shelf\u201d CAR\u2010T, in vivo CAR engineering, and CRISPR\u2010based safety switches further optimize therapeutic potential and accessibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CAR\u2010T therapy represents a promising frontier for refractory neuroautoimmune diseases. By precisely modulating immune networks, it offers a pathway toward long\u2010term remission and personalized immunotherapy in clinical neuroimmunology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70298","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T09:40:39Z","timestamp":1762767639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chimeric Antigen Receptor T\u2010Cell Therapy and Autoimmune Diseases in the Nervous System"],"prefix":"10.1002","volume":"13","author":[{"given":"Shun\u2010yu","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated First Hospital of Hunan Traditional Chinese Medical College Zhuzhou Hunan China"},{"name":"Department of Neurology Affiliated Provincial Traditional Chinese Medical Hospital of Hunan University of Chinese Medicine Zhuzhou Hunan 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