{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T08:46:37Z","timestamp":1792313197739,"version":"4.4.0"},"reference-count":244,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>ROS are pivotal in maintaining periodontal tissue health due to their dual role in physiological and pathological states. At physiological levels, ROS are essential for host defense, effectively eliminating pathogenic bacteria during inflammation and sustaining the homeostasis of the periodontal microenvironment. However, excessive ROS production disrupts the balance between oxidative activity and antioxidant defenses, leading to oxidative stress (OS). This imbalance exacerbates inflammation, damages cellular components, and drives periodontal tissue destruction. Recognizing the dual role of ROS underscores the importance of studying their regulatory mechanisms, which is crucial for advancing understanding and therapeutic strategies in periodontitis management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review summarizes the latest research advancements on the molecular mechanisms linking ROS to the progression of periodontitis and explores related therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review focuses on the pivotal role and specific mechanisms of periodontal tissue destruction by excess ROS, which mediate signaling pathways such as nuclear factor kappa B (NF\u2010\u03baB) and mitogen\u2010activated protein kinase (MAPK), as well as the activation of OS response\u2010associated proteins, including thioredoxin\u2010interacting protein (TXNIP) and mitochondrial antiviral signaling protein (MAVS). Additionally, we provide a concise summary of emerging therapeutic strategies for periodontitis, including the use of antioxidants, photodynamic therapy (PDT), and nanomaterials. Gaining a more profound comprehension of these mechanisms may pave the way for the formulation of enhanced therapeutic strategies for periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Understanding the interplay between ROS and periodontal tissue destruction is essential for advancing periodontitis research. Targeting the NOD\u2010like receptor family pyrin domain\u2010containing 3 (NLRP3) inflammasome with antioxidant and ROS\u2010modulating therapies presents a promising strategy to mitigate both inflammation and OS, thereby reducing periodontal degradation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70301","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T03:59:58Z","timestamp":1764215998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4299-8844","authenticated-orcid":false,"given":"Shuyu","family":"Yang","sequence":"first","affiliation":[{"name":"Stomatological Hospital, School of Stomatology, Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5222-4805","authenticated-orcid":false,"given":"Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"Stomatological Hospital, School of Stomatology, Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07894-0"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.07.012"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2020.1856565"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01724"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.631821"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/b707313e"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1997.tb00760.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183506"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9121211"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02555-9"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e30814"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345231179897"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12304"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2023.2197779"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020737"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01940"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.585917"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24020950"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2017.1340085"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00204"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-016-1223-7"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12945"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12014"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1999.tb00159.x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.314674"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11090489"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12299"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8040222"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2008.00475.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12451"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0615-2"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00910"},{"issue":"5","key":"e_1_2_12_34_1","first-page":"1127","article-title":"Cytochrome B558\u2010Negative, Autosomal Recessive Chronic Granulomatous Disease: Two New Mutations in the Cytochrome B558 Light Chain of the Nadph Oxidase (P22\u2010Phox)","volume":"51","author":"Boer M.","year":"1992","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12951"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-018-0199-6"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00351"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12342"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-021-00134-4"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2013.01.008"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2975"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.01.003"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2551-y"},{"key":"e_1_2_12_44_1","doi-asserted-by":"crossref","unstructured":"M.Herb A.Farid A.Gluschko M.Kr\u00f6nke andM.Schramm \u201cHighly Efficient Transfection of Primary Macrophages With In Vitro Transcribed mRNA \u201dJournal of Visualized Experiments: JoVEno.153(2019):e60143 https:\/\/doi.org\/10.3791\/60143.","DOI":"10.3791\/60143"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143576"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.47.120505.105122"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11101890"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.01.011"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.116003"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2021.2023740"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400656R"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12941"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14286"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.05.019"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019270108"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.09.006"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4923769"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-3063-1"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2008.00555.x"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12395"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x15666171103152136"},{"issue":"5","key":"e_1_2_12_62_1","first-page":"127","article-title":"Effects of Cigarette Smoke Borne Reactive Nitrogen Species on Salivary Alpha\u2010Amylase Activity and Protein Modifications","volume":"60","author":"Weiner D.","year":"2009","journal-title":"Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12101795"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100940"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.12.001"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4446"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.01.008"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124x.118306"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7273"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10027"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.08.009"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2015.11.017"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1700"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041786"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1116509"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-019-0729-1"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17242-0"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.649693"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202306966"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515609097"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-023-00217-4"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2000.tb00325.x"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00494-5"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/mib.0000000000000858"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12860"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25184338"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.10.006"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/986264"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113033"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1995.tb00125.x"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03083-9"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.20-0756"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.09.003"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6447056"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10082161"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.691013"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1192625"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13798"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8624318"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1871-7"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.53.263"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-024-01032-x"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.56.33"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.09.014"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.09.021"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2017.11.002"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14070615"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.05.002"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.11.004"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1134\/s0012496614030132"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066781"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23096"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.10.206"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.03.005"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.01.184"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176102"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-019-0066-x"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.05.020"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.02.012"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.12122\/j.issn.1673-4254.2020.07.05"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0374OC"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.132"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.01.001"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.161"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.08.007"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103304"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S350869"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-018-0168-5"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2016.01.014"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-021-0692-9"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1671430"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3851718"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100196"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00276"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.74575"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105365"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058496"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.S269223"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3893"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116096"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.953277"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00507-5"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010372"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1625"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01357-z"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.19-0222"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4163"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1059576"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202249948"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9091948"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1831"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1269747"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1652244"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.10.001"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7690960"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.054"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.95"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf1933"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100613"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301170"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S341598"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02563"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.01.006"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109166"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020562"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.005"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.07.005"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2017"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6615"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052358"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-2085-6"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.862049"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5617800"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2007.10.007"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09883-w"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2542"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01088"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02530"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12459"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05670-x"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2120453"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.770744"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23781"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12030"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.64.3.16"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02095-x"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13264"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58111605"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00645-4"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.11.007"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-013-1099-4"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-020-01554-9"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2020.1734656"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02416-7"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12647"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13013"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27408-y"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2021.110588"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.23-0335"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052390"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1492"},{"issue":"4","key":"e_1_2_12_206_1","first-page":"729","article-title":"Bioenergetics in Clinical Medicine. Ix. Gingival and Leucocytic Deficiencies of Coenzyme Q10 in Patients With Periodontal Disease","volume":"14","author":"Hansen I. L.","year":"1976","journal-title":"Research Communications in Chemical Pathology and Pharmacology"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513490959"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2018.05.005"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124x.138690"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15204384"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2009.02.003"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00434"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2022.2131117"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2023.02.019"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01418-1"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2022.08.007"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411294"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000029393"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7389"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1520052"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7208"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00302.x"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00346.x"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12816"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.202300400"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10030277"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12123026"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/32488"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-0757-3"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.18-0305"},{"key":"e_1_2_12_231_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-024-04149-1"},{"key":"e_1_2_12_232_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1529520"},{"key":"e_1_2_12_233_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1384344"},{"key":"e_1_2_12_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2024.117962"},{"key":"e_1_2_12_235_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12914"},{"key":"e_1_2_12_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2019.06.002"},{"key":"e_1_2_12_237_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-9668.166100"},{"key":"e_1_2_12_238_1","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2024.42"},{"key":"e_1_2_12_239_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202002081"},{"key":"e_1_2_12_240_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02483-8"},{"key":"e_1_2_12_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110350"},{"key":"e_1_2_12_242_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308587"},{"key":"e_1_2_12_243_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01114-w"},{"key":"e_1_2_12_244_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c01967"},{"key":"e_1_2_12_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120614"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T11:36:50Z","timestamp":1764243410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":244,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/iid3.70301"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70301","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2024-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70301"}}