{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T11:40:19Z","timestamp":1764243619116,"version":"3.46.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human Leukocyte Antigen (HLA) compatibility is a key driver of kidney allograft outcomes, yet how matching interacts with immunosuppressant dosing remains unclear. This study evaluates whether low\u2010resolution HLA match fractions affect mean dosing and quantified the joint impact of match quality and dose on rejection risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 519 transplants grouped by HLA match (0\u20131.0 in 7 strata), full data completeness and variance homogeneity is confirmed, followed by the usage of one\u2010way ANOVA to compare mean doses. Ridge\u2010penalized logistic regression models was fitted at each match level to predict rejection probability across low\u2010 and high\u2010dose regimens, deriving absolute and relative risk reductions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ANOVA showed no significant dosing differences by match (\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>6,512<\/jats:sub>\n                      \u2009=\u20090.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.47). Logistic models revealed that Absolute Risk Reduction rose from ~0.75% at zero match to ~1.25% at perfect match, while mid\u2010range match groups (0.2\u20130.6) yielded the highest total prevented rejections under high\u2010dose therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Uniform baseline dosing eliminates bias, allowing clear attribution of benefit to immunologic compatibility. These findings endorse a risk\u2010tailored immunosuppression approach intensifying doses where match is low and potentially reducing them in highly compatible transplants and identify match ranges that maximize rejection prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70302","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T04:01:13Z","timestamp":1764216073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunosuppression Efficacy via Nonlinear Modeling and Probabilistic Analysis of Human Leukocyte Antigen Match and Dose Effects on Allograft Rejection Risk"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0836-0170","authenticated-orcid":false,"given":"Samrajya Raj","family":"Acharya","sequence":"first","affiliation":[{"name":"Department of Mathematics, School of Science Kathmandu University Dhulikhel Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aayush Man","family":"Regmi","sequence":"additional","affiliation":[{"name":"Department of Mathematics VIT University Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil","family":"Ghimire","sequence":"additional","affiliation":[{"name":"Department of Mathematics, School of Science Kathmandu University Dhulikhel Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram Prasad","family":"Ghimire","sequence":"additional","affiliation":[{"name":"Department of Mathematics, School of Science Kathmandu University Dhulikhel Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"issue":"5","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/TP.0000000000001115","article-title":"The Risk of Transplant Failure With HLA Mismatch in First Adult Kidney Allografts From Deceased Donors","volume":"100","author":"Williams R. C.","year":"2016","journal-title":"Transplantation"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2023.101955"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1447141"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10860917"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58101348"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137357"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1214\/23-aoas1775"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16290"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2023.102675"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.11.030"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-025-04016-3"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16117"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2023.101908"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2012.01654.x"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T11:37:11Z","timestamp":1764243431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/iid3.70302"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70302","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"type":"print","value":"2050-4527"},{"type":"electronic","value":"2050-4527"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70302"}}