{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:13:05Z","timestamp":1782832385178,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiovascular disease, which can be counteracted by physical activity. High\u2010intensity interval training (HIIT) has been shown to improve cardiovascular health, but the effect on disease activity and the level of inflammation in axSpA has been less studied. In the herein presented pilot study, the aim was to investigate if serum levels of inflammatory cytokines, myokines, and protein markers for bone metabolism are acutely affected by one bout of HIIT in individuals with axSpA and healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten participants with axSpA (medication: 6 NSAIDs, 3 biologics, 1 no\u2010treatment) and 11 age\u2010 and sex\u2010matched HC performed a single HIIT bout on a cycle ergometer: 4\u2009\u00d7\u20094 min intervals with 3 min active rest in between. Blood samples were taken before and 1 h after the HIIT bout. Serum proteins (IL\u20106, IL\u201017, IL\u201018, TNF\u2010\u03b1, CXCL\u201010, VEGF\u2010A, BDNF, DKK\u20101, osteoprotegerin, osteocalcin, osteopontin, BMP\u20107, CRP) were analyzed with a Luminex system or ELISA. A two\u2010way ANOVA was used for comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A main effect from baseline to 1 h post HIIT showed that both groups had a significant increase in serum levels of IL\u20106. VEGF\u2010A was significantly lower in the axSpA group but was not affected by the HIIT bout. BMP\u20107 increased in both groups after the HIIT. For the other proteins analyzed, there were no significant differences in serum concentrations between individuals with axSpA and HC, or within the two groups before and after one bout of HIIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One acute bout of HIIT significantly increases the serum concentrations of IL\u20106 and BMP\u20107 after 1 h in both individuals with axSpA and HC, whereas serum levels of other proteins investigated are not changed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70305","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T03:36:03Z","timestamp":1765769763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects on Serum Protein Levels From One Bout of High Intensity Interval Training in Individuals With Axial Spondyloarthritis and Controls"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4360-7710","authenticated-orcid":false,"given":"\u00c5sa","family":"Andersson","sequence":"first","affiliation":[{"name":"Department of Environmental\u2010 and Bioscience Halmstad University Halmstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9337-5113","authenticated-orcid":false,"given":"M. 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