{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:25:16Z","timestamp":1782746716236,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Sepsis frequently results in multiple organ failure, with the liver particularly susceptible to sepsis\u2010induced damage. The flavonoid baicalin (BA), derived from\n                      <jats:italic>Scutellaria baicalensis<\/jats:italic>\n                      , presents anti\u2010inflammatory properties, yet its effects on liver injury in sepsis through the Cluster of Differentiation 14 (CD14)\/Nuclear Factor kappa B (NF\u2010\u03baB) pathway remain underexplored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Alpha Mouse Liver 12 (AML12) cells were intervened with different concentrations of BA and subsequently challenged with lipopolysaccharide (LPS) to induce inflammation. Cell viability, apoptosis, inflammatory cytokine production, and signaling pathway activation were tested by Cell Counting Kit 8 (CCK8), flow cytometry, quantitative real\u2010time PCR (qRT\u2010PCR) and western blotting, respectively. And immunofluorescence was employed to visualize nuclear ectopic location of NF\u2010\u03baB in cells. Additionally, the impact of peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3) silencing for BA's function was explored using small interfering RNA (siRNA) techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BA significantly improved viability and decreased apoptosis in LPS\u2010treated cells. It also downregulated tumor necrosis factor alpha (TNF\u2010\u03b1), interleukin\u20101 beta (IL\u20101\u03b2) and IL\u20106, upregulated PPAR\u03b3, and diminished CD14 and phosphorylated inhibitor of kappa B alpha (p\u2010IKB\u03b1)\/IKB\u03b1 levels. Silencing PPAR\u03b3 reversed the protective effects of BA, underscoring the importance of PPAR\u03b3 in BA's mechanism of action.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BA alleviates sepsis\u2010induced liver injury through activating PPAR\u03b3 and inhibiting CD14\/NF\u2010\u03baB pathway, highlighting its potential as a new approach to treatment sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70319","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:52:48Z","timestamp":1770965568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Baicalin as a Regulator of Peroxisome Proliferator\u2010Activated Receptor Gamma: Alleviating Sepsis\u2010Induced Liver Injury by Inhibiting the Cluster of Differentiation 14\/Nuclear Factor Kappa B Signaling Pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Emergency, Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Emergency, Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Emergency, Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Beijing Ditan Hospital Capital Medical University Beijing 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