{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:19:22Z","timestamp":1787689162921,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alterations in hematological parameters in SARS\u2010CoV\u20102 infection may contribute to disease severity and poor outcomes. This study reports the hematological profile of COVID\u201019 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional study involving 169 confirmed COVID\u201019 patients conducted at Sunyani Teaching Hospital between January and August, 2022. Sociodemographic, clinical, and laboratory data were obtained. Full blood count was performed using an automated hematology analyzer, and systemic inflammatory indices were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants were mostly young adults (51.5%), females (53.8%), resided in urban settings (41.4%), and aged 20\u201081 years with a median age of 35.0 (29.0\u201347.0) years. Overall, anemia was present in 60.4% of the COVID\u201019 patients (56.4% in males and 63.7% in females), with 23.7%, 23.7%, and 13.0% experiencing mild, moderate, and severe anemia, respectively. The COVID\u201019 patients mostly had normocytic normochromic anemia (50.3%), and 37.9% had macrocytic normochromic anemia. Older adults (6.600 times,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), middle\u2010aged adults (4.435 times,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034), and rural dwellers (3.759 times,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) were associated with anemia among the COVID\u201019 patients. Thrombocytopenia was detected in 56.2% of the patients, and 36.7%, 16.0%, and 2.4% had mild, moderate and severe thrombocytopenia respectively. Leucocyte alterations among the patients included leucopenia (22.5%), leucocytosis (17.2%), neutropenia (40.8%), and lymphocytosis (39.6%). Total leucocyte count (AUC: 0.818,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), absolute neutrophil count (AUC: 0.816,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and absolute lymphocyte count (AUC: 0.804,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) predicted severe COVID\u201019 among the participants. Bicytopenia and pancytopenia were observed in 37.3% and 17.8%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>COVID\u201019 is associated with diverse and clinically relevant hematological abnormalities, remarkably anemia, thrombocytopenia, and leucocyte alterations, and usually relate with disease severity. Routine blood cell analysis is essential in the management of COVID\u201019, particularly in resource\u2010limited settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70322","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:24:02Z","timestamp":1768292642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["COVID\u201019\u2010Related Hematological Abnormalities Among Adults; A Cross\u2010Sectional Study in a Resource\u2010Limited Setting"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-9976","authenticated-orcid":false,"given":"Charles","family":"Nkansah","sequence":"first","affiliation":[{"name":"Department of Hematology, School of Allied Health Sciences University for Development Studies Tamale Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-7424","authenticated-orcid":false,"given":"Felix","family":"Osei\u2010Boakye","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology Faculty of Applied Science and Technology, Sunyani Technical University Sunyani Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1855-5840","authenticated-orcid":false,"given":"Samuel K.","family":"Appiah","sequence":"additional","affiliation":[{"name":"Department of Hematology, School of Allied Health Sciences University for Development Studies Tamale Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00028-20"},{"key":"e_1_2_11_3_1","unstructured":"W.H.O. 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