{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T19:24:32Z","timestamp":1769801072456,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate identification of respiratory allergen sensitization is essential for managing asthma and allergic rhinitis (AR). While Skin Prick Test (SPT) and ImmunoCAP are standard diagnostic tools, exploratory comparative data for the novel Allergy Explorer 2 (ALEX\u20102) test in Latin American populations remain scarce. While Skin Prick Test (SPT) and ImmunoCAP are standard diagnostic tools with limited allergen panels per test, the novel Allergy Explorer 2 (ALEX\u20102) multiplex platform can simultaneously assess multiple allergens. However, exploratory comparative data for ALEX\u20102 in Latin American populations remain scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective cross\u2010sectional study evaluated the concordance between SPT, ImmunoCAP, and ALEX\u20102 in detecting respiratory allergen sensitization among 57 patients with asthma or AR recruited consecutively from a private allergy clinic in Lima, Peru. Concordance was assessed using Cohen's\n                      <jats:italic>\u03ba<\/jats:italic>\n                      coefficient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The highest overall agreement was observed between ALEX\u20102 and SPT (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u20090.5649,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), followed by ALEX\u20102 and ImmunoCAP (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u20090.4911,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and ImmunoCAP and SPT (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u20090.4688,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). ALEX\u20102 and ImmunoCAP aligned on 7 of 10 allergens, while both ImmunoCAP and SPT, as well as ALEX\u20102 and SPT, agreed on 5 of 9 allergens. The strongest concordance was found for dust mites, particularly\n                      <jats:italic>Dermatophagoides farinae<\/jats:italic>\n                      (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u20090.6323,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) between ALEX\u20102 and SPT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ALEX\u20102 demonstrates moderate agreement with SPT and ImmunoCAP, with the highest concordance for dust mites, suggesting potential as a complementary diagnostic tool pending validation in diverse populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70325","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:24:09Z","timestamp":1768292649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concordance Analysis of ALEX\u20102, ImmunoCAP, and Prick Test for Respiratory Allergies in Lima, Peru"],"prefix":"10.1002","volume":"14","author":[{"given":"C\u00e9sar A.","family":"Galv\u00e1n","sequence":"first","affiliation":[{"name":"Emedic Salud Lima Peru"},{"name":"Clinical Allergy Service Cl\u00ednica Internacional Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7693-836X","authenticated-orcid":false,"given":"Rafael","family":"Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Human Nutrition and Food Research Group (GINAH) Universidad Cient\u00edfica del Sur Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ignacio","family":"Larco","sequence":"additional","affiliation":[{"name":"Allergy Unit Clinica San Felipe Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Gomez de la Torre","sequence":"additional","affiliation":[{"name":"Laboratorios ROE Lima Peru"},{"name":"Instituto de Investigaciones en Ciencias Biom\u00e9dicas Universidad Ricardo Palma Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12232"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"issue":"2","key":"e_1_2_13_4_1","first-page":"77","article-title":"Factors Associated With Allergic Rhinitis in Children From Northern Mexico City","volume":"17","author":"Del\u2010R\u00edo\u2010Navarro B. E.","year":"2007","journal-title":"Journal of Investigational Allergology & Clinical Immunology"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872006000400008"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.60.04.0015"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4248"},{"issue":"3","key":"e_1_2_13_8_1","first-page":"159","article-title":"Comparison of Specific IgE Detection by Immunoblotting and Fluorescence Enzyme Assay With In Vivo Skin Prick Test","volume":"36","author":"Wongpiyabovorn J.","year":"2018","journal-title":"Asian Pacific Journal of Allergy and Immunology"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.19082\/6327"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2021.10.001"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.32"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8657483"},{"issue":"1","key":"e_1_2_13_13_1","first-page":"20","article-title":"Correlation Between Skin Prick Test and MAST\u2010Immunoblot Results in Patients With Chronic Rhinitis","volume":"31","author":"Kim Y. H.","year":"2013","journal-title":"Asian Pacific Journal of Allergy and Immunology"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14100976"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8657483"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2022-0191"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.008"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.07.036"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/85.3.257"},{"issue":"1","key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.17843\/rpmesp.2020.371.4460","article-title":"Sensibilizaci\u00f3n a Aeroal\u00e9rgenos En Una Poblaci\u00f3n Pedi\u00e1trica Peruana Con Enfermedades Al\u00e9rgicas","volume":"37","author":"Garc\u00eda\u2010Gomero D.","year":"2020","journal-title":"Revista Peruana De Medicina Experimental Y Salud P\u00fablica"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000471511"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-016-0122-3"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.36469\/jheor.2023.77482"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.02.025"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.41"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040653"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.70325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:52:11Z","timestamp":1769748731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/iid3.70325"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70325","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70325"}}