{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:11:15Z","timestamp":1770142275302,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12401648"],"award-info":[{"award-number":["12401648"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11961071"],"award-info":[{"award-number":["11961071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015310","name":"Natural Science Foundation of Xinjiang","doi-asserted-by":"publisher","award":["2021D01C268"],"award-info":[{"award-number":["2021D01C268"]}],"id":[{"id":"10.13039\/501100015310","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about the immune response induced by the SARS\u2010CoV\u20102 Omicron BA.5 variants or the inhaled adenovirus vector vaccine. In this study, we investigated the short\u2010term profile of antireceptor\u2010binding\u2010domain IgG antibody responses elicited by either the virus or the vaccine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort of healthcare workers who were infected with Omicron BA.5 or who received the inhaled adenovirus vector vaccine was identified between August and December 2022. Blood samples were collected twice to detect IgG antibodies against the receptor\u2010binding domain of the SARS\u2010CoV\u20102 spike protein. Baseline characteristics were obtained through questionnaires. Multivariate linear mixed\u2010effect models were applied to assess the changes in IgG antibody levels between the two laboratory test time points, adjusting for baseline covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1146 identified healthcare workers, a total of 419 healthcare workers with known infection status who provided informed consent were eligible for inclusion in the study. The study participants were mostly female (71.8%), had received three doses of intramuscularly injected inactivated vaccine before follow\u2010up (93.8%), and had no comorbidities (94.3%). We estimated that the IgG level increased by 5.1% per week over the 2 months following Omicron BA.5 infection. No significant change in IgG antibody levels in the short term was observed within 1 month after receiving the inhaled adenovirus vector vaccine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggested that the inhaled adenovirus vector vaccine may provide modest protection against Omicron BA.5 infection in the healthcare worker population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70332","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:41:13Z","timestamp":1768884073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010Term Change in IgG Antibody Elicited by Omicron BA.5 Infection and Inhaled Ad5\u2010nCoV Vaccine Among Healthcare Workers"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhaohui","family":"Luo","sequence":"first","affiliation":[{"name":"The Sixth Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Public Health Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Public Health Tianjin Medical University Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[{"name":"The Sixth Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengzhi","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Public Health Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongkang","family":"Ni","sequence":"additional","affiliation":[{"name":"School of Public Health Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Yan","sequence":"additional","affiliation":[{"name":"The Sixth Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Yin","sequence":"additional","affiliation":[{"name":"The Sixth Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Sixth Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering and Technology Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-0483","authenticated-orcid":false,"given":"Zihao","family":"Guo","sequence":"additional","affiliation":[{"name":"JC School of Public Health and Primary Care Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO \u201cCOVID\u201019 Epidemiological Update \u2013 13 August 2024 \u201d WHO cited August 2 2024 https:\/\/www.who.int\/publications\/m\/item\/covid-19-epidemiological-update-edition-170."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2024.01.003"},{"key":"e_1_2_11_4_1","unstructured":"WHO \u201cWeekly Epidemiological Update on COVID\u201019 \u2212 4 January 2023 \u201d WHO cited August 2 2024 https:\/\/www.who.int\/publications\/m\/item\/weekly-epidemiological-update-on-covid-19-4-january-2023."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-02851-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10081309"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.10650"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204336119"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2022.2155251"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00350-X"},{"key":"e_1_2_11_11_1","unstructured":"\u201cCOVID\u2010 19 Clinical and Surveillance Data\u2014Dec 9 2022 to Jan 23 2023 China\u2010 \u201d Chinacdc.cn. cited 2024 August 2 2024 https:\/\/en.chinacdc.cn\/news\/latest\/202301\/t20230126_263523.html."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.5755"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00012-5"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01540-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac167"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00362-0"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2022.2132881"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.31778"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.70332","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:52:05Z","timestamp":1769748725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/iid3.70332"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70332","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70332"}}