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HVEM is known as a receptor of LIGHT (homologous to lymphotoxins, inducible, and competes with HSV glycoprotein D), which is a newly identified member of the TNF superfamily. The expression of HVEM and LTBR (another LIGHT receptor) has been found to be increased in the skin of psoriasis patients. This indicates the potential role of LIGHT and its receptors in the pathogenesis of psoriasis. Therefore, the objective of this study was to examine the effect of LIGHT on keratinocyte proliferation and its therapeutic potential in the treatment of psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used immunohistochemistry to examine their expression in psoriasis\u2010affected and normal tissue samples. We treated cells of the keratinocyte cell line HaCat with LIGHT protein, anti\u2010HVEM and anti\u2010LT\u03b2R antibodies, HVEM interference and LT\u03b2R interference RNA vectors, and NF\u2010\u03baB and JNK\/AP\u20101 inhibitors at various concentrations and for various times, separately or simultaneously. The expression of NF\u2010\u03baB was examined by immunofluorescence staining, and the expression of inflammatory proteins was measured with ELISA. Further, the viability of HaCat cells was examined with a CCK\u20108 kit. In addition, flow cytometry was used to detect the expression of HVEM and LTBR on HaCat cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that LIGHT treatment of HaCat cells promoted the nuclear translocation of NF\u2010\u03baB. Further, the expression of p\u2010c\u2010Jun, IL\u20106, IL\u20108, PGI2, and PTGS2 was increased in response to LIGHT treatment, but the expression of these factors was decreased when the LIGHT receptors were blocked or NF\u2010\u03baB and JNK\/AP\u20101 expression was inhibited. We also found that the viability of HaCat cells was consistent with the expression of pro\u2010inflammatory factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present findings indicate that the JNK\/AP\u20101\u2010HVEM\u2010LIGHT pathway played a role in the viability of human keratinocytes and the expression of IL\u20106, IL\u20108, PGI2, and PTGS2. Thus, the JNK\/AP\u20101\u2010HVEM\u2010LIGHT pathway might be a potential target for the treatment of psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70343","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:13:06Z","timestamp":1770963186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of LIGHT in the Inflammatory Mechanisms of Psoriasis via Upregulation of Proliferation and Cytokine Production of Keratinocytes"],"prefix":"10.1002","volume":"14","author":[{"given":"Cheng\u2010bin","family":"Ye","sequence":"first","affiliation":[{"name":"Allergic Dermatoses Clinical Center, Shanghai Skin Disease Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010wen","family":"Fei","sequence":"additional","affiliation":[{"name":"Allergic Dermatoses Clinical Center, 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