{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:20:47Z","timestamp":1792599647154,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Rheumatoid arthritis (RA) arises from a complex interplay of polygenic susceptibility, epigenetic factors, and environmental modifiers. This study investigated the correlation between RA and Tumor necrosis factor \u03b1\u2010induced protein 3 (TNFAIP3), Interleukin\u20101 receptor\u2010associated kinase 1 (IRAK1), and Toll\u2010like receptor 4 (TLR4) gene polymorphisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A sample of 308 RA cases and 310 matched controls was included. Genotyping of the TNFAIP3, IRAK1, and TLR4 was performed via mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to healthy controls, individuals carrying the rs1059703 A allele (odds ratio (OR)\u2009=\u20090.640, 95% confidence interval (CI): 0.458\u20130.895,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) of IRAK1, individuals carrying the rs5029930 C allele (OR\u2009=\u20090.469, 95% CI: 0.298\u20130.739,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and AC genotype (OR\u2009=\u20090.427, 95% CI: 0.255\u20130.716,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) of TNFAIP3 had a lower RA risk. Individuals carrying the rs5029939 C allele (OR\u2009=\u20092.401, 95% CI: 1.436\u20134.017,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) of TNFAIP3, individuals carrying the rs7873784 C allele (OR\u2009=\u20091.549, 95% CI: 1.101\u20132.179,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), and CG genotype (OR\u2009=\u20091.489, 95% CI: 1.011\u20132.193,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043) of TLR4 had a higher RA risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, the TNFAIP3, IRAK1, and TLR4 gene polymorphisms are associated with RA susceptibility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70344","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:23:18Z","timestamp":1770963798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of TNFAIP3, IRAK1, and TLR4 Gene Polymorphisms in Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhenboyang","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology The Affiliated Hospital of Southwest Medical University Luzhou P.R. 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