{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:40Z","timestamp":1791820960462,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004048","name":"Kashan University of Medical Sciences","doi-asserted-by":"publisher","award":["401148"],"award-info":[{"award-number":["401148"]}],"id":[{"id":"10.13039\/501100004048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD), also referred to as atopic eczema, is one of the most common immunological disorders in children. Previous studies have suggested potential roles of interleukin\u201033 (IL\u201033) in the onset and progression of AD. This study investigated whether serum IL\u201033 levels in children with AD are associated with disease severity, immunoglobulin E (IgE) sensitization to food or environmental allergens, and serum IgE concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 62 children with newly diagnosed AD and 30 age\u2010matched healthy controls. Following an interview and confirmation of disease severity, 3mL of venous blood was collected from each participant. Sensitization to allergens was assessed using a skin prick test. Serum IL\u201033 (ng\/L) and IgE (IU\/mL) levels were measured using enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 62 children with AD, 51 (82.3%) were sensitized to food allergens, whereas 11 (17.7%) were sensitized to environmental allergens. Most patients (75.8%) had mild AD. Serum IL\u201033 and IgE levels were significantly elevated in patients compared with healthy controls. Both IL\u201033 and IgE concentrations were significantly associated with moderate AD. However, IL\u201033 levels were not correlated with age, gender, or allergen type. Receiver operating characteristic (ROC) analysis revealed that IgE levels demonstrated moderate diagnostic performance for AD (AUCc0.758), while IL\u201033 showed weaker diagnostic value (AUC\u2009=\u20090.678). For predicting disease severity, IL\u201033 exhibited strong performance, with the highest sensitivity (85.71%) and maximum specificity (70.21%) at a cut\u2010off of 331.32\u2009ng\/L (AUC\u2009=\u20090.862). In contrast, IgE was not a reliable predictor of AD severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum IL\u201033 levels are significantly correlated with AD severity and may serve as a predictive biomarker, whereas IgE shows limited utility for severity assessment. Further studies are warranted to validate the clinical applicability of IL\u201033 in AD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70351","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:29:01Z","timestamp":1770614941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predicting Role of Interleukin\u201033 in Determining the Development and Severity of Atopic Dermatitis"],"prefix":"10.1002","volume":"14","author":[{"given":"Ali\u2010reza","family":"Ghasemiyeh","sequence":"first","affiliation":[{"name":"Pediatric Department, School of Medicine Kashan University of Medical Sciences Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh Heidarzadeh","family":"Arani","sequence":"additional","affiliation":[{"name":"Pediatric Department, School of Medicine Kashan University of Medical Sciences Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Riazian","sequence":"additional","affiliation":[{"name":"Department of Biology, Science and Research Branch Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Aghajani","sequence":"additional","affiliation":[{"name":"Clinical Diagnostic Laboratory Matini Hospital, Kashan University of Medical Sciences Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Javad","family":"Azadchehr","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Center Kashan University of Medical Sciences Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7372-4590","authenticated-orcid":false,"given":"Hossein","family":"Motedayyen","sequence":"additional","affiliation":[{"name":"Autoimmune Diseases Research Center Kashan University of Medical Sciences Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-01642-z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJSA_37_2024"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.008"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"35","article-title":"Atopic Dermatitis: An Overview","volume":"86","author":"Berke R.","year":"2012","journal-title":"American Family Physician"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.030"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"A. 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