{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:00:51Z","timestamp":1782316851658,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study aimed to investigate the prevalence, associated clinical manifestations, and co\u2010infection patterns of\n                      <jats:italic>Mycoplasma genitalium<\/jats:italic>\n                      (MG) infection among patients attending Venereal Disease, Urology, and Gynecology clinics in Hangzhou, China. The findings provide foundational evidence to guide sexually transmitted infection (STI) screening in patients with genitourinary tract conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between January 2020 and December 2023, 12,934 outpatients from Hangzhou Third People's Hospital were tested for MG using isothermal amplification targeting the 16S rRNA gene. Concurrent testing for\n                      <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n                      (NG),\n                      <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                      (CT), and\n                      <jats:italic>Ureaplasma urealyticum<\/jats:italic>\n                      (UU) was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of these 12,934 patients, 589 tested positive for MG, yielding an overall prevalence of 4.55% (589\/12,934). Prevalence was significantly higher in males (416\/7915, 5.26%) than in females (173\/5,019, 3.44%). Significant age\u2010related differences were observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with the highest prevalence in patients \u2264\u200920 years 7.83% and the lowest in those &gt;\u200960 years 0.57%. Of 416 MG\u2010positive males, 295 (70.91%) exhibited symptoms of urethritis, prostatitis, and epididymitis. whereas 49.71% (86\/173) of MG\u2010positive females exhibited vaginitis, cervicitis, or pelvic inflammatory disease (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Symptomatic infection rates were significantly higher in males than in females. Co\u2010infections were found in 44.31% (261\/589) of MG\u2010positive patients, with MG\u2009+\u2009UU co\u2010infection being the most frequent 22.92% (135\/589).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MG infection prevalence in Hangzhou is substantial, with significantly higher rates among males and young adults (\u2264\u200920 years). Females exhibit markedly lower symptomatic infection rates. MG demonstrates frequent co\u2010infection, predominantly with UU, underscoring the necessity of multipathogen testing to prevent missed diagnoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70357","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:45:50Z","timestamp":1770709550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiology of\n                    <i>Mycoplasma genitalium<\/i>\n                    Infections of the Genitourinary Tract Among Attendees of STI Clinic in Hangzhou, China"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3635-789X","authenticated-orcid":false,"given":"Xinmin","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Clinical laboratory Hangzhou Third People's Hospital Hangzhou Zhejiang People's Republic of 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