{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:10:13Z","timestamp":1773011413380,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kikuchi\u2013Fujimoto disease (KFD) is a rare condition characterized by elevated serum ferritin levels and a robust immune response involving various lymphocyte subtypes. However, the relationship between ferritin and lymphocyte subtypes remains unexplored. This study aims to offer insights into the immune response in KFD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010five hospitalized patients diagnosed with KFD through histopathological examination were categorized into hyperferritinemia and control groups. Baseline characteristics, ultrasound findings, and laboratory results were retrospectively collected for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Biopsied lymph nodes in KFD patients were predominantly located in the neck (89.2%), followed by the axilla (6.2%) and submandible (4.6%). These nodes exhibited a mean long diameter of 2.3\u2009mm (interquartile range [IQR] 2.0\u20132.8\u2009mm) and a mean short diameter of 0.9\u2009mm (IQR 0.7\u20131.2\u2009mm). A comparison between the hyperferritinemia and control groups revealed significant differences: Serum ferritin levels were 664.4\u2009\u00b5g\/L (IQR 450.5\u2013963.9\u2009\u00b5g\/L) vs. 111.3\u2009\u00b5g\/L (IQR 75.7\u2013207.4\u2009\u00b5g\/L), respectively. Additionally, counts of CD3+ and CD4+ lymphocytes, as well as NK cells, were reduced in the hyperferritinemia group: CD4+ lymphocyte counts were 387.7\u2009cells\/\u00b5L (IQR 261.5\u2013479.7\u2009cells\/\u00b5L) vs. 479.9 cells\/\u00b5L (IQR 396.2\u2013662.0 cells\/\u00b5L),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021; and the percentage of CD4+ lymphocytes was 33.8% (IQR 29.4\u201041.7%) vs. 42.4% (IQR 40.4\u201348.6%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000. Furthermore, serum ferritin levels exhibited a linear positive correlation with CRP (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.420,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and a negative correlation with CD4+ lymphocyte count (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.412,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and percentage of CD4+ lymphocytes (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.567,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with KFD demonstrated immunosuppression characterized by decreased counts of circulating CD3+ and CD4+ lymphocytes, as well as NK cells. Moreover, serum ferritin levels were inversely correlated with CD4+ lymphocyte counts, suggesting a potential role of ferritin in immune dysregulation in KFD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70358","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:30:06Z","timestamp":1770964206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Negative Correlation Between Serum Ferritin and CD4+ Lymphocytes: A Retrospective Study on Kikuchi\u2010Fujimoto Disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Peng","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Beijing Friendship Hospital Capital Medical University Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiwen","family":"Sang","sequence":"additional","affiliation":[{"name":"Medical College of Shanxi Datong University Datong Shanxi People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Beijing Friendship Hospital Capital Medical University Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5199-0110","authenticated-orcid":false,"given":"Zhenzhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Trauma Center, Peking University People's Hospital Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0219-RA"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.540305.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.08.019"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14050"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605241248884"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1269"},{"issue":"7","key":"e_1_2_11_8_1","first-page":"2551","article-title":"Association of Increased Levels of Heavy\u2010Chain Ferritin With Increased CD4+ CD25+ Regulatory T\u2010Cell Levels in Patients With Melanoma","volume":"9","author":"Gray C. 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