{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:56:41Z","timestamp":1787497001775,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bronchopulmonary dysplasia (BPD) is a chronic lung disease characterized by inflammation, often caused by prolonged hyperoxia exposure in preterm infants. Platelet\u2010activating factor (PAF) is a potent inflammatory mediator, but its role in BPD is unclear. This study explores the therapeutic potential of the PAF receptor antagonist Ginkgolide B (GB) in hyperoxia\u2010induced lung injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We observed the activation status of platelets and neutrophils in BALF\uff08bronchoalveolar lavage fluid) of patients with BPD. The supernatant of BALF from patients was sent for protein chip detection and validated by ELISA. We also measured the levels of PAF in peripheral blood and BALF. In vitro experiments, we stimulated neutrophils with PAF to detect the expression of inflammatory cytokine genes. Finally, we established a neonatal rat model of hyperoxia\u2010induced lung injury mimicking BPD and intervened with GB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed early activation of platelets and neutrophils in the peripheral blood of BPD patients, with elevated plasma levels of PAF and myeloperoxidase\u2010DNA (MPO\u2010DNA). In BALF, neutrophils showed increased CD66b and MPO expression. In vitro, PAF stimulation decreased CD62L expression on neutrophils and upregulated IL\u20106 mRNA. Elevated levels of PAF, IL\u20106, IL\u20108, and GM\u2010CSF were found in BPD infants' BALF supernatant. Using animal models of BPD, we found that GB significantly reduced lung damage in hyperoxia\u2010exposed rats. GB decreased neutrophil\u2010derived IL\u20106 and downregulated key proteins in the IL\u20106 signaling pathway (pJak2 and pStat3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrates that PAF activates neutrophils and promotes their lung residence. GB effectively inhibits neutrophil\u2010derived IL\u20106 and alleviates hyperoxia\u2010induced lung damage. Targeting the PAF pathway with GB may be a promising strategy for BPD and other hyperoxia\u2010related lung diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70364","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:15:56Z","timestamp":1775114156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ginkgolide B Alleviates Airway Inflammation in Hyperoxia Lung Injury"],"prefix":"10.1002","volume":"14","author":[{"given":"Xuesong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of USTC, 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