{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:05:18Z","timestamp":1773014718372,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite advances in lung cancer treatment, early mortality following Systemic Anticancer Therapy (SACT) remains a major concern. Identifying patients at high risk of early mortality may inform treatment decision\u2010making, particularly where SACT may offer limited benefit. We aimed to quantify spatiotemporal patterns of early mortality following SACT and to examine the relative contributions of individual\u2010 and area\u2010level risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a secondary analysis of data from the Victorian Lung Cancer Registry. Bayesian spatiotemporal multilevel models were used to assess associations between individual\u2010 and area\u2010level factors and early mortality following SACT. Adjusted Odds Ratios (AORs) with 95% Credible Interval (Crl) were reported to indicate statistical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Substantial spatiotemporal variation in early mortality following SACT was observed across Victoria. Factors associated with increased odds of early mortality included age \u2265\u200960\u2009years (AOR\u2009=\u20091.06, 95% Crl: 1.01\u20131.22), clinical stage II (AOR\u2009=\u20091.15, 95% Crl: 1.01\u20131.59), stage III (AOR\u2009=\u20091.28, 95% Crl: 1.01\u20132.05), stage IV (AOR\u2009=\u20093.19, 95% Crl: 2.12\u20135.07), comorbidity (AOR\u2009=\u20091.12, 95% Crl: 1.01\u20131.34), and poor performance status (AOR\u2009=\u20093.09, 95% Crl: 2.24\u20134.24). Presentation at a multidisciplinary meeting (AOR\u2009=\u20090.66, 95% Crl: 0.52\u20130.88) and receipt of supportive care screening (AOR\u2009=\u20090.53, 95% Crl: 0.41\u20130.69) were associated with reduced odds of early mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Marked spatiotemporal variation in early mortality following SACT highlights the need for targeted, risk\u2010informed treatment strategies, particularly for patients with advanced disease, comorbidities, poor performance status, and those residing in high\u2010risk areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70368","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:19:51Z","timestamp":1771395591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Mortality Following Systemic Anticancer Therapy in Lung Cancer: A Bayesian Spatiotemporal Multilevel Analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6812-1659","authenticated-orcid":false,"given":"Getayeneh Antehunegn","family":"Tesema","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia"},{"name":"Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences University of Gondar Gondar Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob G.","family":"Stirling","sequence":"additional","affiliation":[{"name":"Central Clinical School, Faculty of Medicine, Nursing and Health Sciences Monash University Melbourne Victoria Australia"},{"name":"Department of Respiratory Medicine Alfred Health Melbourne Victoria 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