{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:03:17Z","timestamp":1787497397357,"version":"build-2736575974"},"reference-count":127,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Amyloid beta plaques and tau tangles are the primary hallmarks of Alzheimer's disease (AD). Recently, passive anti\u2010A\u03b2 immunotherapy for AD has markedly advanced, as supported by evidence from AD animal models and clinical trials. Whereas innate immunity significantly contributes to AD pathology, it does not fully represent the immune mechanisms linked to this condition. Therefore, focus should be directed toward adaptive immunity, encompassing both humoral and cellular immunity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant publications and clinical trial data up to February 2026 were systematically reviewed to summarize the mechanisms, therapeutic targets, safety profiles, and translational applications of CD8+ T cells in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinical and animal studies have particularly suggested a potential involvement of T cells in AD pathogenesis. T cells that infiltrate the central nervous system (CNS) exert both protective and detrimental effects on neural tissue in AD. Because autoreactive CD8+ T cells are generally expected to have cytotoxic effects on CNS cells, they have received less attention. Nevertheless, accumulating evidence suggests that CD8+ Treg cells are involved in various diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>However, the function of anti\u2010A\u03b2\u2010specific CD8+ T cells in Alzheimer's disease (AD) remains ambiguous. Many subsets of CD8+ T cells have been well\u2010studied in autoimmunity. We suggest that CD8+ T cell subsets identified in AD studies may constitute a promising area for future AD research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70380","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:59:39Z","timestamp":1772999979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["New Perspective: Bench to Bedside Evidence of the Role of CD8+ T Cells in Alzheimer's Disease"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-7668","authenticated-orcid":false,"given":"Yong","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Hunan Traditional Chinese Medical College (Hunan Provincial Directly Affiliated Hospital of Traditional Chinese Medicine) Zhuzhou Hunan China"},{"name":"Department of Geriatric Medicine First Affiliated Hospital of Hunan Traditional Chinese Medical College (Hunan Provincial Directly Affiliated Hospital of Traditional Chinese Medicine) Zhuzhou Hunan China"},{"name":"Department of Neurology Provincial Hospital of Traditional Chinese Medicine Affiliated to Hunan University of Traditional Chinese Medicine Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun\u2010yu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Hunan Traditional Chinese Medical College (Hunan Provincial Directly Affiliated Hospital of Traditional Chinese Medicine) Zhuzhou Hunan China"},{"name":"Department of Neurology Provincial Hospital of Traditional Chinese Medicine Affiliated to Hunan University of Traditional Chinese Medicine Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Liang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine First Affiliated Hospital of Hunan Traditional Chinese Medical College (Hunan Provincial Directly Affiliated Hospital of Traditional Chinese Medicine) Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xiangya Hospital, Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Science and Technology Innovation Hunan University of Chinese Medicine Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugimoto","family":"Kazuo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dongzhimen Hospital Beijing University of Chinese Medicine Beijing China"},{"name":"Institute for Brain Disorders at Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dongzhimen Hospital Beijing University of Chinese Medicine Beijing China"},{"name":"Institute for Brain Disorders at Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao\u2010qiao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Hunan Traditional Chinese Medical College (Hunan Provincial Directly Affiliated Hospital of Traditional Chinese Medicine) Zhuzhou Hunan China"},{"name":"Department of Neurology Provincial Hospital of Traditional Chinese Medicine Affiliated to Hunan University of Traditional Chinese Medicine Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan\u2010xin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Hunan Traditional Chinese Medical College (Hunan Provincial Directly Affiliated Hospital of Traditional Chinese Medicine) Zhuzhou Hunan China"},{"name":"Department of Neurology Provincial Hospital of Traditional Chinese Medicine Affiliated to Hunan University of Traditional Chinese Medicine Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010hui","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Hunan Traditional Chinese Medical College (Hunan Provincial Directly Affiliated Hospital of Traditional Chinese Medicine) Zhuzhou Hunan China"},{"name":"Department of Neurology Provincial Hospital of Traditional Chinese Medicine Affiliated to Hunan University of Traditional Chinese Medicine Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai\u2010yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Hunan Traditional Chinese Medical College (Hunan Provincial Directly Affiliated Hospital of Traditional Chinese Medicine) Zhuzhou Hunan China"},{"name":"Department of Geriatric Medicine First Affiliated Hospital of Hunan Traditional Chinese Medical College (Hunan Provincial Directly Affiliated Hospital of Traditional Chinese Medicine) Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.021"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1206572"},{"key":"e_1_2_12_4_1","article-title":"True or False? Alzheimer'S Disease is Type 3 Diabetes: Evidences From Bench to Bedside","volume":"102383","author":"Peng Y.","year":"2024","journal-title":"Ageing Research Reviews"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207156"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105326"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0281-2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.09.001"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00391-w"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa098"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.05.018"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207268"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01546-6"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.340409"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228541"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4668"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006277"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3441-12.2013"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1472"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1315248"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaf092"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2024.149393"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2022.06.005"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00692-7"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125529"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/22124"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.07.002"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34538-5"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00294-0"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000240466.10758.ce"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz142"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2022.06.012"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100708"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01369-8"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3392"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3710"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00069-8"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.1.255"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0051-1"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110647"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.08.008"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2010"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.348"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3913"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2965"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1015"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:7:3:255"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-091696"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4626540"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200947"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000247740.47667.03"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803982"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0507296"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-017-0013-5"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116549"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1006-08.2008"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4022"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1895-7"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-04965-7"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000551"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.4103\/2311-8571.328617"},{"key":"e_1_2_12_67_1","first-page":"521","article-title":"Characterization of Proteolipid Protein\u2010Peptide\u2010Specific Cd(4)(+) T Cell of Experimental Allergic Encephalomyelitis in Biozzi Ab\/H Mice","volume":"115","author":"Peng Y.","year":"2002","journal-title":"Chinese Medical Journal"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1851"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.05.070"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.019"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2401420121"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02308-7"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00375-7"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01213"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.01.003"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.75965"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301707"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0317-5"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.04.019"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-102034"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2216"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.16"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01781"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020783"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.03.004"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.03.008"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj8222"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000159740.16984.3C"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000073623.84147.A8"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm840"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2004.tb00493.x"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e03844"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70043-0"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-015-0108-3"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900620"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(03)00036-8"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.03.061"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.08.036"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003953"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.017"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.708874"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.06.003"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1189"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12103"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12020308"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.01.013"},{"key":"e_1_2_12_107_1","first-page":"11","article-title":"Resident Memory\u2010Like Cd8(+) T Cells are Involved in Chronic Inflammatory and Neurodegenerative Diseases in the Cns","author":"Kimura K.","year":"2024","journal-title":"Neurology(R) neuroimmunology & neuroinflammation"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01415-3"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.75965"},{"key":"e_1_2_12_110_1","article-title":"Antigen\u2010Specifically Activated Cd8+ And Double\u2010Negative T Cells Accumulate In The Brain Of Alzheimer's Disease Mice","author":"Gellrich J.","year":"2025","journal-title":"Aging and Disease"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62405-6"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02198-4"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-022-10056-5"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-008-9138-6"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2011.11.005"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.888946"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(92)90284-R"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2023.10.058"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1315248"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-954591"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8300-y"},{"key":"e_1_2_12_122_1","first-page":"2498","article-title":"Ribosomal Proteins are Blood Biomarkers and Associated With Cd4+ T Cell Activation in Alzheimer's Disease: A Study Based on Machine Learning Strategies and Scrna\u2010Seq Data Validation","volume":"15","author":"Wang Y.","year":"2023","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002083"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/nep3.38"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000551"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.01.010"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1995.1078"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.768229"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70380","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.70380","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:17:13Z","timestamp":1776143833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":127,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/iid3.70380"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70380","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70380"}}