{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:37:29Z","timestamp":1793907449684,"version":"4.8.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ulcerative colitis (UC), a form of inflammatory bowel disease (IBD), increases the risk of colorectal cancer. This study investigates the potential of conditioned medium from mesenchymal stem cells (CMm) treated with 17\u2010beta\u2010estradiol (E2) to enhance colon regeneration in UC\u2010affected rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Bone marrow\u2010derived MSCs from male Wistar rats were cultured with 100\u2009nM E2 for 24\u2009h. UC was induced in three groups: colitis (C), mesenchymal stem cells (MSC), and MSCs\u2009+\u2009estradiol (MSC\u2009+\u2009E2). Each group received intraperitoneal injections of 200\u2009\u00b5L CMm derived from 2\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      cells or E2\u2010treated CMm three times postinduction. The study evaluated disease activity index (DAI), myeloperoxidase (MPO) levels, nitric oxide (NO), and pro\u2010inflammatory cytokines (TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106) in colon tissues, alongside histopathological assessments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results showed significant improvements in DAI and reductions in MPO, NO, and cytokine levels in MSC and MSC\u2009+\u2009E2 groups compared to the C group. Histopathological analysis revealed enhanced colon tissue regeneration in these groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that CMm, particularly with E2, may facilitate colonic healing and mitigate inflammation in UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70387","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:33:05Z","timestamp":1773005585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Enhanced Colon Regeneration in Ulcerative Colitis via Mesenchymal Stem Cell Medium and 17\u2010\u03b2 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