{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:59:03Z","timestamp":1776146343740,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Scrub typhus, lacks specific early symptoms, and traditional serological tests have low sensitivity. This study shows that CD64 has superior diagnostic performance compared to CRP and PCT in bacterial infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study analyzed 242 febrile patients admitted to the Jiangsu Province (Suqian) Hospital (January 2023\u2013December 2024), categorized into non\u2010specific fever (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009186) and scrub typhus (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956). The CD64 expression was quantified via flow cytometry (BD FACS Canto II) within 48\u2009h of admission. ROC analysis evaluated diagnostic performance using AUC, sensitivity, specificity, and Youden index. Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      and Chi\u2010square tests compared groups (SPSS v26.0), with significance at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The scrub typhus group had significantly higher CD64 levels (median: 2.90 [IQR: 1.00\u20135.20]) than non\u2010specific fever (0.23 [0.10\u20130.58],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). ROC analysis demonstrated CD64's high discriminatory power: AUC\u2009=\u20090.938 (95% CI: 0.882\u20130.995) for scrub typhus vs. non\u2010specific fever (sensitivity\u2009=\u200991.7%, specificity\u2009=\u200989.8%). Traditional markers like WBC and lymphocyte percentage showed high discrimination against non\u2010specific fever (AUC\u2009=\u20090.973\u20130.989).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study shows that CD64 is an efficient biomarker for differentiating scrub typhus from febrile diseases, offering crucial evidence for establishing rapid diagnostic pathways and holding value for early triage of febrile patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70396","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:50:18Z","timestamp":1774331418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Value of Neutrophil CD64 in Differentiating Scrub Typhus From Febrile Diseases"],"prefix":"10.1002","volume":"14","author":[{"given":"Jing","family":"Su","sequence":"first","affiliation":[{"name":"Jiangsu Province (Suqian) Hospital Suqian Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyi","family":"Chen","sequence":"additional","affiliation":[{"name":"The Suqian Clinical College of Xuzhou Medical University Suqian Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Jiangsu Province (Suqian) Hospital Suqian Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Province (Suqian) Hospital Suqian Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenya","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Province (Suqian) Hospital Suqian Jiangsu 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