{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:59:18Z","timestamp":1776146358875,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Psoriasis is a recurrent immune\u2010mediated systemic disease. Adiponectin (APN), a key regulator of metabolism, is also known for its anti\u2010inflammatory properties in several inflammatory disorders. The study aims to investigate the anti\u2010inflammatory properties of APN on human immortalized keratinocyte cells (HaCaT) and to evaluate its therapeutic potential in an imiquimod (IMQ)\u2010induced psoriasis mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HaCaT cells were treated with 5, 10, or 20\u2009\u03bcg\/ml APN, and cell viability was assessed. A psoriasis\u2010like cellular model was created by exposing HaCaT cells to TNF\u2010\u03b1 (50\u2009ng\/ml) for a duration of 24\u2009h. Apoptosis was analyzed using flow cytometry, and the secretion of inflammatory cytokines was measured through enzyme\u2010linked immunosorbent assay (ELISA). Real\u2010time quantitative polymerase chain reaction (RT\u2010qPCR) was used to measure the mRNA expression levels of AdipoR1, AdipoR2, and T\u2010cadherin(T\u2010cad). Aurora kinase A (AURKA) and Forkhead transcription factor 1 (FOXM1) were analyzed using Western blotting (WB) and RT\u2010qPCR. The anti\u2010psoriatic effect of APN was also evaluated in IMQ\u2010induced psoriatic dermatitis. Additionally, ELISA and WB were used to assess cytokines and key signaling proteins in mouse skin tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>APN significantly inhibited the proliferation of HaCaT cells and enhanced their apoptosis. Additionally, it decreased the production of interleukin (IL)\u20101\u03b2, IL\u20108, and IL\u20106. APN upregulated AdipoR1 and AdipoR2 mRNA levels while downregulating the mRNA and protein levels of T\u2010cad. Mechanistically, APN mitigated the inflammatory response in keratinocytes by suppressing the TNF\u2010\u03b1\u2010induced upregulation of AURKA and FOXM1. This mechanism was substantiated in vivo, where APN treatment alleviated IMQ\u2010induced psoriatic dermatitis in mice, concurrently reducing levels of IL\u20101\u03b2, CXCL2 and IL\u20106, and modulating the expression of AdipoR1, AdipoR2, AURKA, and FOXM1 in mouse skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that APN inhibits keratinocyte hyperproliferation and suppresses inflammation in TNF\u2010\u03b1\u2010induced keratinocytes. Moreover, APN treatment attenuates IMQ\u2010induced psoriatic dermatitis in mice, supporting its potential as a therapeutic approach for psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70407","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:58:12Z","timestamp":1774331892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adiponectin Inhibits AURKA to Suppress Inflammation in TNF\u2010\u03b1\u2010induced Keratinocytes and Attenuates Psoriatic Dermatitis in Mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Lingling","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Soochow University Suzhou China"},{"name":"Department of Dermatology Gongli Hospital of Shanghai Pudong New Area Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxi","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Suzhou Municipal Hospital Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Jiao","sequence":"additional","affiliation":[{"name":"Central Research laboratory The First Affiliated Hospital of Soochow University Suzhou China"},{"name":"Department of Dermatology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8888-3690","authenticated-orcid":false,"given":"Jiang","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103326"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2018.1557201"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512930"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.2909"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08902.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.311"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106428"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010078"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvae160"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8687"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3282bf6ea8"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-021-01510-z"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjw011"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12020663"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S385894"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10123.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02555"},{"issue":"6","key":"e_1_2_12_20_1","first-page":"3047","article-title":"Anti\u2010Obesity and Fatty Liver\u2010Preventing Activities of Lonicera Caerulea in High\u2010Fat Diet\u2010Fed Mice","volume":"42","author":"Kim J. 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