{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:00:48Z","timestamp":1789664448103,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Critical illnesses, particularly sepsis with accompanying organ dysfunction, significantly increase patient mortality. The imbalance between pro\u2010inflammatory and anti\u2010inflammatory responses is closely linked to the onset and progression of organ dysfunction in critical conditions. The ratio of interleukin\u20106 (IL6) to interleukin\u201010 (IL10) is a useful indicator of the pro\u2010 and anti\u2010inflammatory status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the correlation between IL6\/IL10 and various outcomes, including organ function, in critically ill patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study was conducted from 1 January to 31 May 2023 at Peking Union Medical College Hospital. Baseline characteristics, intensive care unit (ICU) parameters, laboratory test results, and outcome data were extracted from the electronic medical records system. Correlations between IL6\/IL10 and various outcomes, including organ function, were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      In total, 208 patients were included in the study. Higher IL6\/IL10 levels were associated with shorter in\u2010hospital stay, ICU stay, and mechanical ventilation time in both univariate and multivariate models. The \u03b2 values and 95% confidence intervals in the multivariate model were \u22120.526 (\u2212\u20090.684, \u22120.369), \u22120.183 (\u2212\u20090.245, \u22120.121), and \u22121.510 (\u2212\u20092.565, \u22120.456), respectively. Significant positive associations between IL6\/IL10 and all organ functions except the platelet count and PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio were found. Sensitivity analyses in the sepsis group revealed significant correlations with nearly every organ function (except liver function) in patients without tumors and those who underwent surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study showed that in critically ill patients, particularly those with sepsis, IL6\/IL10 is significantly associated with outcomes such as organ dysfunction (including coagulation, renal, cardiac, and pulmonary function). These findings are hypothesis\u2010generating, suggesting that IL6\/IL10 may serve as a valuable indicator associated with inflammation and severity changes in critical illness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70414","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:15:52Z","timestamp":1775801752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship Between IL6\/IL10 Serum Concentrations and Organ Function in Critically Ill Patients Based on Sepsis: A Prospective Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Guang\u2010Jian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Health Care, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing 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