{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:52:23Z","timestamp":1791431543011,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) is a major cause of lower respiratory infections (LRIs), especially in children, the elderly, and immunocompromised individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using GBD 1990\u20132021 data, we analyzed global RSV\u2010related LRI deaths and DALYs. Trends were assessed via age\u2010standardized rates and joinpoint regression. We also examined regional and demographic disparities and their association with the Sociodemographic Index (SDI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2021, RSV\u2010related LRIs caused 31,525.1 deaths and 2.59 million DALYs globally, marking a 78.9% decrease since 1990. The greatest decline occurred between 2020 and 2021. South Asia and Sub\u2010Saharan Africa showed the highest burden. Children under 5 and the elderly (80+) were most affected, particularly males. A negative correlation was observed between SDI and disease burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RSV burden has declined, but remains high in low\u2010SDI regions. Sustained public health efforts and vaccination are critical to further reduce impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70415","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T06:09:03Z","timestamp":1777010943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Respiratory Syncytial Virus on the Global Burden of Lower Respiratory Infections: Lessons From the Global Burden of Disease Study 1990\u20132021"],"prefix":"10.1002","volume":"14","author":[{"given":"Jiafen","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Xiantao First People's Hospital Xiantao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Huanggang Hospital of Traditional Chinese Medicine Hubei University of Chinese Medicine Huanggang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hubei Provincial Hospital of Traditional Chinese Medicine\/Affiliated Hospital of Hubei University of Chinese Medicine Wuhan Hubei China"},{"name":"Hubei Shizhen Laboratory Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0345-5063","authenticated-orcid":false,"given":"Feng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Xiangyang Hospital of Traditional Chinese Medicine (Xiangyang Institute of Traditional Chinese Medicine) Hubei University of Chinese Medicine Xiangyang 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