{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:45:00Z","timestamp":1777632300777,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This current study aimed to detect the risk factors for recurrence of the anti\u2010synthetase syndrome related interstitial lung disease (ASSD\u2010ILD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who were diagnosed with ASSD\u2010ILD and achieved the improving standards after treatment at a single clinical center from January 1, 2017 to January 1, 2022 were retrospectively collected. The patients were divided into the recurrence group and non\u2010recurrence group. We compared the baseline information, pulmonary function test, chest computed tomography\/high\u2010resolution computed tomography (CT\/HRCT) images, and treatments et al between the two groups. Cox regression was performed to find risk factors for recurrence. Moreover, the Kaplan\u2010Meier curve was conducted to estimate the recurrence\u2010free rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Totally 76 ASSD\u2010ILD patients were collected in this study. There were 24 patients in the recurrence group and 52 patients in the non\u2010recurrence group. The recurrence rate was 31.6%. Univariate analysis showed that pyrexia of unknown origin, neutrophil percentage &gt;\u200975%, non\u2010specific interstitial pneumonia (NSIP) alone pattern, and immunosuppressants discontinuation were associated with recurrence (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In the primary IPTW\u2010weighted Cox model, pyrexia of unknown origin was significantly associated with recurrence (HR\u2009=\u20092.70, 95% CI: 1.12\u20136.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027). In sensitivity analyses using a doubly robust IPTW\u2010weighted Cox model, both pyrexia of unknown origin (HR\u2009=\u20095.17, 95% CI: 1.94\u201313.78,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and NSIP alone pattern (HR\u2009=\u20090.30, 95% CI: 0.11\u20130.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) remained significantly associated with recurrence. Furthermore, the Kaplan\u2010Meier curve demonstrated that the non\u2010NSIP group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039) and the pyrexia of unknown origin group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) had worse recurrence\u2010free rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients with ASSD\u2010ILD there is a high frequency of recurrence. The results suggested that pyrexia of unknown origin was a risk factor for recurrence. A follow\u2010up strategy, customized treatment, and early surveillance for high\u2010risk patients who relapse were critical to enhancing patients' quality of life and prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70417","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:34:28Z","timestamp":1776753268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors for Recurrence of the Anti\u2010Synthetase Syndrome Related Interstitial Lung Disease"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-983X","authenticated-orcid":false,"given":"Zhen\u2010Yu","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"Chongqing Red Cross Hospital Chongqing 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