{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:44:43Z","timestamp":1777632283130,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) is the main cause of bronchiolitis in infants. This systematic review aimed to evaluate the burden of RSV\u2010associated bronchiolitis among hospitalized Italian infants between 2000 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search identified studies examining RSV\u2010related hospitalizations for bronchiolitis in children aged 0\u201359 months. Eligible studies met the following criteria: conducted in Italy, focused on children, reported on RSV prevalence, co\u2010infections, genotype distribution (RSV\u2010A, RSV\u2010B), and seasonal trends, and published in English or Italian. Data extraction focused on study design, infant characteristics (e.g., age, preterm birth), and RSV detection methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010four studies were included. Infants under 12 months were most affected. RSV was the primary pathogen identified, though co\u2010infections with other respiratory viruses, such as human rhinovirus, were common. RSV infections typically peaked in late autumn and winter, but the COVID\u201019 pandemic altered these patterns. This review highlights the significant burden of RSV\u2010associated bronchiolitis in Italian infants. While RSV remains the primary pathogen, co\u2010infections and pandemic related factors have altered its epidemiological trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nationwide RSV immunization programmes and improved diagnostics are crucial to ease the strain on pediatric intensive care units. Recent recommendations for widespread RSV long\u2010acting monoclonal antibody use in infants offer promising solutions to address this challenge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70420","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:30:32Z","timestamp":1776231032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Burden and Characteristics of Respiratory Syncytial Virus\u2010Associated Bronchiolitis in Hospitalized Infants in Italy: A Systematic Review"],"prefix":"10.1002","volume":"14","author":[{"given":"Angela","family":"Bechini","sequence":"first","affiliation":[{"name":"Department of Health Sciences University of Florence Florence 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