{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:09:55Z","timestamp":1785326995796,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>Osteoarthritis (OA) is a chronic and degenerative joint disorder that is prevalent in middle\u2010aged and older populations. While several long non\u2010coding RNAs (lncRNAs) have been implicated in OA progression, the role of lncRNA Mirt2 and its regulatory mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The expression of lncRNA Mirt2, miR\u2010429, and TANK\u2010binding kinase 1 (TBK1) was detected using qRT\u2010PCR in normal and OA cartilage tissues. The interleukin (IL)\u22121\u03b2\u2010stimulated chondrocyte was used as an in vitro OA cell. EdU, TUNEL assay, western blot, and ELISA assays were used for our experiments. Luciferase reporter assays, RNA immunoprecipitation (RIP), and RNA pulldown were used to investigate the interactions between lncRNA Mirt2, miR\u2010429, and TBK1. An\n                      <jats:italic>in vivo<\/jats:italic>\n                      OA model was established, and cartilage damage was evaluated using H\/E and Safranin O\/Fast Green staining.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LncRNA Mirt2 expression was significantly downregulated in OA cartilage tissues and IL\u20101\u03b2\u2010stimulated chondrocytes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Transfection of the lncRNA Mirt2 overexpression vector led to a remarkable increase in cell proliferation, a significant reduction in cell apoptosis and inflammation, and a marked elevation in autophagy in IL\u20101\u03b2\u2010induced chondrocytes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Functional investigation revealed that lncRNA Mirt2 acts as a competing endogenous RNA (ceRNA) by sponging miR\u2010429 in IL\u20101\u03b2\u2010induced chondrocytes. Additionally, miR\u2010429 directly targets TBK1. Rescue experiments showed that overexpression of miR\u2010429 or inhibition of TBK1 effectively counteracted the functional consequences of lncRNA Mirt2 upregulation in IL\u20101\u03b2\u2010stimulated chondrocytes, reversing its promotive effects on cell proliferation and autophagy, as well as its inhibitory effect on apoptosis. The\n                      <jats:italic>in vivo<\/jats:italic>\n                      experiments indicated overexpression of lncRNA Mirt2 down\u2010regulated miR\u2010429, up\u2010regulated TBK1, substantially attenuated cartilage damage, and accelerated autophagy in OA mice (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LncRNA Mirt2 promoted chondrocyte proliferation and alleviated chondrocyte apoptosis, inflammation, and cartilage degeneration by activating miR\u2010429\/TBK1\u2010mediated autophagy. Consequently, lncRNA Mirt2 could be a potential target for OA diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70423","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:36:22Z","timestamp":1783406182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LncRNA Mirt2 Attenuates Osteoarthritis Progression by Promoting miR\u2010429\/TBK1\u2010Mediated Autophagy"],"prefix":"10.1002","volume":"14","author":[{"given":"Jian\u2010xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedic Weinan Central hospital Weinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Weinan Central hospital Weinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Weinan Central hospital Weinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Weinan Central hospital Weinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Weinan Central hospital Weinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Weinan Central hospital Weinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0321-4395","authenticated-orcid":false,"given":"Hong\u2010bo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Weinan Central hospital Weinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2019.10.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/ORR.S442025"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052619"},{"issue":"2","key":"e_1_2_10_6_1","first-page":"155","article-title":"An Insight Into Osteoarthritis Susceptibility: Integration of Immunological and Genetic Background","volume":"21","author":"Stefik D.","year":"2021","journal-title":"Bosnian Journal of Basic Medical Sciences"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.03.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00447-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12254"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530319666190904161707"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02229-1"},{"issue":"5","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/etm.2020.9159","article-title":"Long Non\u2011Coding RNA Mirt2 Interacts With Long Non\u2011Coding RNA IFNG\u2011AS1 to Regulate Ulcerative Colitis","volume":"20","author":"Li C.","year":"2020","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.02.096"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-020-00504-2"},{"issue":"11","key":"e_1_2_10_15_1","first-page":"6299","article-title":"The Effect of Myocardial Infarction\u2010Associated Transcript 2 (Mirt2) and miR\u2010101 on Sepsis\u2010Induced Myocardial Injury in Rats","volume":"24","author":"Zhang X. 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