{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:44:37Z","timestamp":1777632277813,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Recent studies have shown that significant expression of PrP\n                      <jats:sup>C<\/jats:sup>\n                      protein is also present in skeletal muscle, and it plays a significant role in maintaining skeletal muscle homeostasis. Although the expression of PrP\n                      <jats:sup>C<\/jats:sup>\n                      in skeletal muscle has been clarified, the effects of PrP\n                      <jats:sup>Sc<\/jats:sup>\n                      \u2010mediated prion protein infection on sarcopenia in mice and its potential regulatory mechanisms remain unclear. This study investigated the role of PrP\n                      <jats:sup>C<\/jats:sup>\n                      in Prion\u2010induced sarcopenia, using an animal model of prion disease based on intraperitoneal injection of the scrapie strain ME7 into wild\u2010type mice and Prnp knockout mice. The results indicate that prion infection\u2010induced sarcopenia exhibits muscle fiber type specificity, and that the lack of PrP\n                      <jats:sup>C<\/jats:sup>\n                      can prevent prion protein infection\u2010induced sarcopenia, although the lack of PrP\n                      <jats:sup>C<\/jats:sup>\n                      may lead to reduced mitochondrial\u2010endoplasmic reticulum homeostasis. These data provide novel evidence that prion infection affects skeletal muscle system health through myofiber\u2010specific mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70425","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:12:21Z","timestamp":1776143541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Prnp<\/i>\n                    Deletion Mitigates Muscle Fiber Type\u2010Specific Sarcopenia Induced by Prion Infection in Mice"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6967-6842","authenticated-orcid":false,"given":"Wenduo","family":"Liu","sequence":"first","affiliation":[{"name":"College of Physical Education Beihua University Jilin City Jilin China"},{"name":"Department of Sports Science, College of Natural Science Jeonbuk National University Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Chan","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology Gyeongkuk National University Andong Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae\u2010Young","family":"Won","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology Gyeongkuk National University Andong Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8140-9778","authenticated-orcid":false,"given":"Thi Thu Trang","family":"Kieu","sequence":"additional","affiliation":[{"name":"Department of Bioactive Material Sciences, Research Center of Bioactive Materials Jeonbuk National University Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Ho","family":"Kook","sequence":"additional","affiliation":[{"name":"Department of Bioactive Material Sciences, Research Center of Bioactive Materials Jeonbuk National University Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-9994","authenticated-orcid":false,"given":"Byung\u2010Hoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Bioactive Material Sciences, Research Center of Bioactive Materials Jeonbuk National University Jeonju Republic of Korea"},{"name":"Korea Zoonosis Research Institute Jeonbuk National University Iksan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Sports Science, College of Natural Science Jeonbuk National University Jeonju Republic of 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