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In contrast, this review integrates these obesity\u2010related events within a unified immunometabolic framework centered on ATMs. Obesity induces marked phenotypic shifts and metabolic reprogramming in ATMs, thereby promoting chronic inflammation and IR. Disturbed fatty acid metabolism and gut microbiota dysbiosis further impair metabolic homeostasis and intestinal barrier integrity, reinforcing a vicious cycle of macrophage\u2010driven immunometabolic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review highlights the central role of ATM\u2010mediated immune\u2010metabolic crosstalk in obesity and emphasizes the therapeutic potential of targeting macrophage dysfunction and gut microbiota alterations to attenuate obesity\u2010related metabolic complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70470","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:15:01Z","timestamp":1786961701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunometabolic Dysregulation in 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