{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:26Z","timestamp":1786977926474,"version":"build-2736575974"},"reference-count":94,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder driven by inflammation, in which the NLRP3 inflammasome plays a central role. Current targeted inhibitors face challenges in patient stratification and long\u2010term safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative literature review was conducted using PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Google Scholar from database inception to February 2026. Search terms included combinations of \u201cnon\u2010alcoholic fatty liver disease\u201d, \u201cNAFLD\u201d, \u201cNASH\u201d, \u201cNLRP3 inflammasome\u201d, \u201ctraditional Chinese medicine\u201d, \u201cTCM\u201d, \u201cherbal medicine\u201d, \u201csyndrome differentiation\u201d, and \u201cprecision medicine\u201d. Peer\u2010reviewed original articles, systematic reviews, and clinical studies addressing NLRP3 in NAFLD or TCM\u2010based interventions targeting this pathway were prioritized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TCM syndrome patterns (e.g., damp\u2010heat, phlegm\u2010damp) correlate with distinct NLRP3 activation states and inflammatory phenotypes. Herbal compounds such as berberine and curcumin, as well as classical TCM formulae, exert multi\u2010target effects by suppressing NLRP3 inflammasome assembly, enhancing antioxidant defenses, and modulating the gut\u2010liver axis. Based on this evidence, we propose an integrative \u201cTCM Syndrome\u2013NLRP3 Molecular Endotype\u2013Precision Targeted Therapy\u201d model that links specific TCM syndromes to canonical, non\u2010canonical, or sustained NLRP3 activation, thereby providing hypothesis\u2010driven strategies for personalized intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This integrative framework bridges TCM holistic principles with modern inflammasome biology. It provides a theoretical basis for personalized, biomarker\u2010driven NAFLD therapies, highlighting the synergy between traditional medicine and precision hepatology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70474","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:53:58Z","timestamp":1781758438000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["TCM\u2010Guided Targeted Therapies Against NLRP3 Inflammasome in NAFLD"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3972-5158","authenticated-orcid":false,"given":"Yanxia","family":"Zhang","sequence":"first","affiliation":[{"name":"Shandong Xinzhonglu Traditional Chinese Medicine Hospital Jinan Shandong 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