{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:09:46Z","timestamp":1785326986892,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic rhinitis (AR) is a prevalent chronic inflammatory condition characterized by nasal itching, sneezing, and congestion, significantly impairing patients' quality of life. Despite the availability of various therapeutic options, treatment efficacy remains suboptimal for certain patients, and long\u2010term use may be accompanied by adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study examined the role of transient receptor potential melastatin 2 (TRPM2) in AR\u2010like inflammation, focusing on its associations with T cell functionality, Th2 inflammatory responses, Treg\/Th17 balance, and upstream Ca\n                      <jats:sup>2+<\/jats:sup>\n                      \u2010NFAT signaling pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using TRPM2 knockout and WT mice within an ovalbumin\u2010induced AR model, this research integrated behavioral assessments, histopathological analyses, immunological assays, qPCR, and Western blotting to evaluate the implications of TRPM2 deficiency for clinical symptoms, inflammatory responses, immune cell differentiation, and related signaling pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TRPM2 knockout mice exhibited reduced clinical symptoms and nasal inflammation, lower serum OVA\u2010specific IgE levels, and reduced expression of key inflammatory cytokines, including IL\u20104, IL\u20105, and IL\u201033. Furthermore, TRPM2 deficiency was associated with expansion of Treg cells, reduced Ca\n                      <jats:sup>2+<\/jats:sup>\n                      influx, decreased NFATc1 nuclear translocation, and lower IL\u20102 production. Although IL\u201017 expression was reduced, the decrease in Th17 cell frequency did not reach statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings suggest that TRPM2 participates in OVA\u2010induced AR\u2010like inflammation through immune and Ca\n                      <jats:sup>2+<\/jats:sup>\n                      \u2010NFAT\u2010associated mechanisms, while the mechanistic and translational implications require cautious interpretation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70490","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:52:27Z","timestamp":1783921947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRPM2 Deficiency Attenuates Allergic Rhinitis\u2010Like Inflammation With Altered Ca\n                    <sup>2+<\/sup>\n                    \u2010NFAT Signaling, Treg Responses, and sIgE Production"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhenke","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3600-9628","authenticated-orcid":false,"given":"Lixin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S536944"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113816128388496250812102820"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxaf060"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111380"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000699"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.147789"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1224129"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155663"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7034078"},{"issue":"5","key":"e_1_2_11_11_1","article-title":"Emerging Novel Biomarkers in Allergic Rhinitis: A Narrative Review","volume":"17","author":"Mishra T.","year":"2025","journal-title":"Cureus"},{"issue":"1","key":"e_1_2_11_12_1","first-page":"2","article-title":"Relationship Between Mode of Delivery and the Development of Allergic Rhinitis: A Systematic Review and Meta\u2010Analysis","volume":"63","author":"Hoang M. 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