{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:20:06Z","timestamp":1791595206929,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The clinical relevance of inherited thrombophilia\u2010related polymorphisms in COVID\u201019 remains uncertain. This study investigated the distribution of Factor V Leiden (FVL) G1691A and MTHFR A1298C polymorphisms in patients with COVID\u201019 and associations with laboratory findings and short\u2010term mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2010control study included 150 patients with PCR\u2010confirmed COVID\u201019 and 300 controls. Genomic DNA was isolated from peripheral blood, and FVL G1691A and MTHFR A1298C polymorphisms were analyzed. Associations with d\u2010dimer levels, hospitalization duration, and 30\u2010 and 90\u2010day mortality were evaluated using multivariable linear and Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The FVL GG genotype was less frequent in patients than controls (77.3% vs. 87.0%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009), whereas the MTHFR AA genotype was more frequent (76.7% vs. 61.3%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001). Heterozygosity in both genes did not differ between groups (8.0% vs. 6.3%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.552). Patients with heterozygosity in both genes had higher d\u2010dimer levels (median 435.0 vs. 201.0 ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.024) and longer hospitalization (median 7.5 vs. 5.0 days,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.037). After adjustment, heterozygosity in both genes remained associated with higher log\u2010transformed d\u2010dimer levels (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.758, 95% CI: 0.239\u20131.277;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005), as did MTHFR A1298C (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.432, 95% CI: 0.007\u20130.856;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.046). None of the polymorphisms was associated with 30\u2010 or 90\u2010day mortality, while age independently predicted both outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thrombophilia\u2010related polymorphisms may influence d\u2010dimer levels and hospitalization duration in COVID\u201019 but do not appear to affect short\u2010term mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70493","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:10:51Z","timestamp":1785143451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Case\u2013Control Study of Factor V Leiden G1691A and MTHFR A1298C Polymorphisms and Clinical Outcomes in Patients With COVID\u201019"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3742-0262","authenticated-orcid":false,"given":"Hilal","family":"\u00c7\u0131ral\u0131o\u011flu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Pamukkale University Faculty of Medicine Denizli T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-4816","authenticated-orcid":false,"given":"Yasemin","family":"Adal\u0131","sequence":"additional","affiliation":[{"name":"Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"},{"name":"Division of Epidemiology, Department of Public Health, Faculty of Medicine Pamukkale University Denizli T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6653-3756","authenticated-orcid":false,"given":"Mert","family":"\u00d6zen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Pamukkale University Faculty of Medicine Denizli T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4373-6280","authenticated-orcid":false,"given":"Alten","family":"Oskay","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Pamukkale University Faculty of Medicine Denizli T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-5681","authenticated-orcid":false,"given":"Atakan","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Pamukkale University Faculty of Medicine Denizli T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-9471","authenticated-orcid":false,"given":"Murat","family":"Seyit","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Pamukkale University Faculty of Medicine Denizli T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-0436","authenticated-orcid":false,"given":"Aylin","family":"K\u00f6seler","sequence":"additional","affiliation":[{"name":"Department of Biophysics Pamukkale University Faculty of Medicine Denizli T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8342-4615","authenticated-orcid":false,"given":"\u0130brahim","family":"T\u00fcrk\u00e7\u00fcer","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Pamukkale University Faculty of Medicine Denizli T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10060993"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1730967"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12372"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181faa0f2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v90i10-S.8758"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9825-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2023.01.017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg024"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100639"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.47419\/bjbabs.v3i03.141"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/HEMATOLREP15020024"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/TJB-2021-0183\/XML"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8166-7-s1-p28"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.18225"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105919"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.024156"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.47582\/JOMPAC.1140392"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28457"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-020-01136-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2020.101226"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242127"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03498-2020"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2020-0198"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.70493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:52:09Z","timestamp":1785325929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/iid3.70493"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70493","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70493"}}