{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:34:09Z","timestamp":1793201649588,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Central Line\u2010Associated Bloodstream Infections (CLABSIs) considered a significant challenge in healthcare settings, necessitating vigilant monitoring and intervention strategies especially among patients undergoing Hematopoietic Stem Cell Transplantation (HSCT). This study aims to conduct comprehensive analysis of CLABSI cases among HSCT patients; trends in incidence, device associations, causative organisms, and multidrug\u2010resistant patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on HSCT patients who developed CLABSI at the King Hussein Cancer Center between January 2019 and December 2023. Data collected included demographic data (age and sex), Diagnosis, type of vascular access device (VAD), Organism, bacterial resistance pattern, and last follow\u2010up status and date were collected for patients. Overall survival analysis was performed using the Kaplan\u2013Meier method, with results reported at 30, 60, and 100 days post\u2010infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over the 5\u2010year period, 169 HSCT patients had CLABSI were included, the majority were male (65.7%), with 73% adults and 27% pediatric patients, and a mean age of 33.6 years. The most common diagnoses were lymphoma (25.4%) and leukemias (24.9%). Gram\u2010negative bacteria were the predominant cause of infection, accounting for 85% of cases, followed by Gram\u2010positive bacteria (13.0%) and fungi (2.4%).\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      was the most frequent causative organism (46%), followed by\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      (8%) and\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (5%). Multidrug\u2010resistant pathogens, particularly Extended\u2010Spectrum Beta\u2010Lactamase (ESBL) producing strains and Carbapenem\u2010resistant\n                      <jats:italic>Enterobacteriaceae<\/jats:italic>\n                      (CRE), were prevalent. Hickman devices were associated with the highest number of CLABSI cases (63.9%). The overall survival rates were 83.4% at 30 days, 80.5% at 60 days, and 78.1% at 100 days post\u2010CLABSI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides a comprehensive overview of CLABSI epidemiology among HSCT patients in Jordan, highlighting the high prevalence of Gram\u2010negative and multidrug\u2010resistant organisms. These findings underscore the critical need for continuous surveillance, targeted infection control measures, and effective antimicrobial stewardship to improve patient safety and outcomes in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70495","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:09:23Z","timestamp":1786961363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological Trends and Multidrug\u2010Resistant Patterns in Central Line\u2010Associated Bloodstream Infections Among Bone Marrow Transplant Patients at Comprehensive Cancer Center in Jordan: Five\u2010Year Retrospective Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Sawsan","family":"Mubarak","sequence":"first","affiliation":[{"name":"Infection Control Program King Hussein Cancer Center Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joud","family":"Jarrah","sequence":"additional","affiliation":[{"name":"Department of Medicine King Hussein Cancer Center Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-4379","authenticated-orcid":false,"given":"Hadeel","family":"AlGhawrie","sequence":"additional","affiliation":[{"name":"Infection Control Program King Hussein Cancer Center Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Khresat","sequence":"additional","affiliation":[{"name":"Infection Control Program King Hussein Cancer Center Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Department of Adult Blood and Bone Marrow Transplantation (BMT) | KHCC [Internet]. [Cited November 9 2025].https:\/\/www.khcc.jo\/en\/adults-bone-marrow-transplant."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2005.04.001"},{"key":"e_1_2_11_4_1","unstructured":"Changing Microbial Epidemiology in Hematopoietic Stem Cell Transplant Recipients: Increasing Resistance Over a 9\u2010Year Period \u2010 Macesic \u2212 2014 \u2010 Transplant Infectious Disease \u2010 Wiley Online Library [Internet]. [Cited November 4 2025].https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/tid.12298?casa_token=FyoquGrOC4AAAAAA%3ACGMqRK5QWUTu5YjJa06VoWcuZzUiLtGNUu6OWkyOGVT1TBNpvEmbmEOqd-MGLKmbOr9pDA2AC9cZEqA09w."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2018.03.004"},{"key":"e_1_2_11_6_1","unstructured":"Bloodstream Infections. CDC NHSN. 2025 January;."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir257"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/668431"},{"key":"e_1_2_11_9_1","unstructured":"Association of CLABSI With Hospital Length of Stay Readmission Rates and Mortality: A Retrospective Review \u2010 Chovanec \u2212 2021 \u2010 Worldviews on Evidence\u2010Based Nursing \u2010 Wiley Online Library [Internet]. [Cited November 11 2025].https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/wvn.12548."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.04.031"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnci.2013.12.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2023.08.010"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjpediatr.2024.4529"},{"key":"e_1_2_11_14_1","unstructured":"Central Line Associated Blood Stream Infection: Microbiological Profile and Its Antimicrobial Susceptibility Pattern at Tertiary Care Centre [Internet]. Journal of Pure and Applied Microbiology. 2023 [Cited November 5 2025].https:\/\/microbiologyjournal.org\/central-line-associated-blood-stream-infection-microbiological-profile-and-its-antimicrobial-susceptibility-pattern-at-tertiary-care-centre\/."},{"key":"e_1_2_11_15_1","unstructured":"From Access to Reserve: Antimicrobial Resistance Among Etiological Agents of Central Line\u2010Associated Bloodstream Infections in the View of WHO's AWaRe Antimicrobial Spectrum | Publisso [Internet]. [Cited November 5 2025].https:\/\/journals.publisso.de\/en\/journals\/hic\/volume20\/dgkh000559."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16061239"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S392804"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-023-01338-5"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2025.02.010"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12727"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2015.10.008"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2015.12.012"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1179\/2047773215Y.0000000030"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2009.06.008"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61865-X"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix690"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.70495","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:07:50Z","timestamp":1793200070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/iid3.70495"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70495","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70495"}}